Results 91 to 100 of about 4,674,041 (304)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

TanDEM-X Scientific Results and Future Formation Flying SAR Missions [PDF]

, 2011
TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurements) is an innovative spaceborne radar interferometer mission that was launched on June 21, 2010. This paper gives an overview of scientific experiments that have been conducted during the TanDEM-
Lopez Dekker, Paco, De Zan, Francesco, Hajnsek, Irena, Rodriguez Cassola, Marc, Zink, Manfred, Moreira, Alberto, Prats, Pau, Baumgartner, Stefan, Papathanassiou, Konstantinos, Krieger, Gerhard   +9 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Flight Dynamics Operations of the TanDEM-X Formation [PDF]

, 2012
Since end of 2010 the German TerraSAR-X and TanDEM-X satellites are routinely operated as the first configurable single-pass Synthetic Aperture Radar interferometer in space. The two 1340 kg satellites fly in a 514 km sun-synchronous orbit.
Aida, Saika, Schlepp, Benjamin, Kirschner, Michael, Kahle, Ralph, Wermuth, Martin   +4 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The TanDEM-X Acquisition Timeline and Mission Plan [PDF]

, 2008
This paper introduces the TanDEM-X data acquisition plan that fulfils the requirements of deriving a global DEM according to the emerging HRTI-3 quality standard within three years mission time. Therefore, a joint TerraSAR-X and TanDEM-X data acquisition
Zink, Manfred, Geyer, Michael, Fiedler, Hauke, Jäger, Jürgen, Krieger, Gerhard   +4 more
core  

Using TanDEM-X Pursuit Monostatic Observations with a Large Perpendicular Baseline to Extract Glacial Topography

Remote Sensing, 2018
Space-based Interferometric Synthetic Aperture Radar (InSAR) applications have been widely used to monitor the cryosphere over past decades. Owing to temporal decorrelation, interferometric coherence often severely degrades on fast moving glaciers ...
Sang-Hoon Hong, Shimon Wdowinski, Falk Amelung, Hyun-Cheol Kim, Joong-Sun Won, Sang-Wan Kim   +5 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source