Results 141 to 150 of about 348,025 (296)

Tandem Duplications in the Human Genome

open access: yes, 2008
Profound knowledge about the nature of mutational processes is essential for a comprehensive understanding of the evolutionary mechanisms that change genomes over time. The aim of the thesis is to elucidate the role of DNA insertions and deletions in this context. Compared with nucleotide substitutions, these types of mutations are far less understood.
openaire   +2 more sources

The TanDEM-X Acquisition Timeline and Mission Plan [PDF]

open access: yes, 2008
This paper introduces the TanDEM-X data acquisition plan that fulfils the requirements of deriving a global DEM according to the emerging HRTI-3 quality standard within three years mission time. Therefore, a joint TerraSAR-X and TanDEM-X data acquisition
Zink, Manfred   +4 more
core  

The TanDEM-X Mission Concept [PDF]

open access: yes, 2008
TanDEM-X opens a new era in space borne radar remote sensing. The first bistatic SAR mission, is formed by adding a second, almost identical spacecraft, to TerraSAR-X and flying the two satellites in a closely controlled formation with typical distances ...
Zink, Manfred   +3 more
core  

Seasonal Fluctuations of Plastochromanol‐8 and α‐Tocopherol Amounts in the Leaves of Cecropia Trees

open access: yesJournal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Plastochromanol‐8 (PC‐8) is a homologue of γ‐tocotrienol with a longer side chain (eight instead of three isoprene units) and therefore also a representative of the tocochromanol (vitamin E) group. PC‐8 has been determined in various plants and seeds, with Cecropia sp. leaves showing unusually high levels.
Rosalie Ormos, Jörg Rau, Walter Vetter
wiley   +1 more source

TPS genes expression pattern and terpenoids content in the leaves and flowers of Chimonanthus praecox and C. salicifolius

open access: yesScientific Reports
Chimonanthus spp. has attracted much attention due to its great ornamental value and potential medicinal value. The flowers of Chimonanthus praecox and C. salicifolius exude a strong aroma.
Wei Zou   +6 more
doaj   +1 more source

Critical questions for documenting collections as data: Provocations from developing datasheets for web archives datasets

open access: yesJournal of the Association for Information Science and Technology, EarlyView.
Abstract Scholarship on documentation of datasets is increasingly concerned with capturing the context, socio‐technical processes, and decisions shaping data. “Datasheets for datasets” is a recent approach developed by researchers in machine learning that foregrounds transparency and uncovering bias through data documentation.
Emily Maemura, Helena Byrne
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg   +7 more
wiley   +1 more source

Maximum Cardinalities for Tandem and Palindromic Duplication Correcting Codes

open access: yes, 2017
Maximum cardinalities for tandem and palindromic duplication correcting codebooks are derived by employing the generalized sphere packing ...
Lenz, A.; Wachter-Zeh, A.
core  

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum   +5 more
wiley   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen   +14 more
wiley   +1 more source

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