Results 191 to 200 of about 47,309 (261)

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, EarlyView.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia

The FEBS Journal, EarlyView.
Genetic rearrangements resulting in the expression of KMT2A fusion alleles can lead to dramatic transcriptional disturbances that contribute to the onset of acute leukaemias. Fortunately, menin inhibition has emerged as a promising new class of targeted therapy.
Lydia Elaine Roets, Graeme Greenfield, Katrina Mairead Lappin   +2 more
wiley   +1 more source

Genome and transcriptome‐based identification and expression profiling of chemosensory gene families across developmental stages and tissues in Sirex noctilio (Hymenoptera: Siricidae)

Insect Molecular Biology, EarlyView.
The first draft genome of Sirex noctilio was produced. Fifteen S. noctilio transcriptomes were sequenced to study chemosensory gene expression patterns. SnocOR16 and SnocSNMP1 displayed tissue‐ and sex‐specific expression patterns. Abstract The Sirex woodwasp (Sirex noctilio; Hymenoptera: Siricidae) is among the most destructive invasive pests ...
Alisa Postma, Leandri Klynsmith, Tuan A. Duong, Jeremy Dean Allison, Werner Smidt, Robert M. Waterhouse, Peter Lesny, Jan Philip Oeyen, Malte Petersen, Sebastian Martin, Shanlin Liu, Xin Zhou, Tanja Ziesmann, Alexander Donath, Christoph Mayer, Bernhard Misof, Oliver Niehuis, Ralph S. Peters, Lars Podsiadlowski, Martin P. A. Coetzee, Fourie Joubert, Bernard Slippers   +21 more
wiley   +1 more source

An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function. [PDF]

Nat Commun
Li Y, Wang Q, Jia H, Ishikawa K, Kosami KI, Ueba T, Tsujimoto A, Yamanaka M, Yabumoto Y, Miki D, Sasaki E, Fukao Y, Fujiwara M, Kaneko-Kawano T, Tan L, Kojima C, Wing RA, Sebastian A, Nishimura H, Fukada F, Niu Q, Shimizu M, Yoshida K, Terauchi R, Shimamoto K, Kawano Y.   +25 more
europepmc   +1 more source

A unified formulation for home healthcare routing and scheduling problems

International Transactions in Operational Research, EarlyView.
Abstract Home Healthcare is an essential component of healthcare systems, where caregivers visit patients' homes to deliver services. While presenting advantages with respect to institutional care, such as being cost‐effective and alleviating family burdens, it presents challenges in scheduling and routing caregivers efficiently.
Sara Ceschia, Francesca Da Ros, Luca Di Gaspero, Simona Mancini, Vittorio Maniezzo, Roberto Montemanni, Roberto Maria Rosati, Andrea Schaerf   +7 more
wiley   +1 more source

The improved prognosis of FLT3-internal tandem duplication but not tyrosine kinase domain mutations in acute myeloid leukemia in the era of targeted therapy: a real-world study using large-scale electronic health record data. [PDF]

Haematologica
Schwede M, Rodriguez G, Kennedy VE, Henry S, Wood D, Mannis GN, Majeti R, Chen JH, Bendavid E, Zhang TY.   +9 more
europepmc   +1 more source

Mapping Nursing Roles in Long‐Term Care: A Systematic Review With Network Analysis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise evidence on nurses' roles in long‐term care settings and map their interactions. Design Systematic review with network analysis. Methods Thematic synthesis was used to identify nurses' roles, and network analysis mapped their interactions across domains. Data Sources Six databases—Cumulative Index to Nursing and Allied Health
Kyong Hee Park, Hye‐Ryoung Kim
wiley   +1 more source

A phase II study of ponatinib for prevention of relapse after allogeneic transplantation in <i>FLT3</i> internal tandem duplication mutation-positive (<i>FLT3</i>^-ITD⁺) acute myeloid leukemia: the PONALLO trial. [PDF]

Haematologica
Chevallier P, Thiebaut A, François S, Chantepie S, Rubio MT, Labussiere-Wallet H, Brissot E, Maillard N, Huynh A, Coiteux V, Jullien M, Garnier A, Le Bourgeois A, Peterlin P, Guillaume T.   +14 more
europepmc   +1 more source

Barriers and Enablers to Pre‐Registration Nurses Providing Safe Care for Individuals Experiencing Suicidal Distress: A Scoping Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To identify research gaps by mapping what is known about the barriers and enablers to pre‐registration nursing students identifying signs of suicidal distress in healthcare consumers and providing clear pathways of support. Design Scoping review.
Renee Molloy, Brent Hayward, Samantha Scott, Alison Hansen, Adam Searby   +4 more
wiley   +1 more source