Results 191 to 200 of about 612,525 (237)

Inverted tandem duplication generates a duplication deficiency of chromosome 8p

Clinical Genetics, 1987
An adult female with severe mental retardation and dysmorphic features is described. A de novo chromosomal aberration involving 8p was found. The karyotype was 46, XX, inv dup (8) (pl2→p23.1). Dosage studies with the DNA probe D8S7, which is located at 8p23→8pter, showed that the patient was monosomic for this marker.
F J, Dill, M, Schertzer, J, Sandercock, B, Tischler, S, Wood   +4 more
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Sequence Alignment with Tandem Duplication

Journal of Computational Biology, 1997
Algorithm development for comparing and aligning biological sequences has, until recently, been based on the SI model of mutational events which assumes that modification of sequences proceeds through any of the operations of substitution, insertion or deletion (the latter two collectively termed indels). While this model has worked fairly well, it has
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Tandem duplications in Drosophila melanogaster

Chromosoma, 1973
In the tandem duplication Dp(1;1)Gr approximately one quarter of the euchromatic part of the X-chromosome is duplicated. Dp(1;1)Gr itself has no phenotypic effect, but it can be made visible by combining different alleles within the tandem duplication and the homologous X-chromosome.
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Selection for Gene Clustering by Tandem Duplication

Annual Review of Microbiology, 2004
▪ Abstract  In prokaryotic genomes, related genes are frequently clustered in operons and higher-order arrangements that reflect functional context. Organization emerges despite rearrangements that constantly shuffle gene and operon order. Evidence is presented that the tandem duplication of related genes acts as a driving evolutionary force in the ...
Andrew B, Reams, Ellen L, Neidle
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Tandem duplications in Drosophila melanogaster II. Meiotic pairing and exchange in heterozygous tandem duplications

Theoretical and Applied Genetics, 1975
In heterozygous females of tandem duplication Dp(1; 1) Gr, y(2) (w(-)spl sn(3)) (w(c) sn(3)) the frequency and distribution of exchange events were measured by the phenotypically different F1 recombinants. In comparison with wild type chromosomes the crossover values were strongly reduced within the heterozygous chromosome sections (between white and ...
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Carcinogens induce genetic tandem duplications in Salmonella

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1985
Extensive studies have shown that chemical carcinogenesis involves an initiation-promotion pattern. A gene amplification model of carcinogenesis predicts that initiation involves induction of a genetic tandem duplication. We use a system developed by Anderson and Roth to select for tandem duplication of the histidine operon of Salmonella typhimurium by
M L, Pall, B J, Hunter
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