Results 201 to 210 of about 887,704 (273)

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

Effects of Emergent Carotid Stenting Performed before or after Mechanical Thrombectomy in the Endovascular Management of Patients with Tandem Lesions: A Multicenter Retrospective Matched Analysis. [PDF]

AJNR Am J Neuroradiol
Scarcia L, Colò F, Alexandre AM, Brunetti V, Pedicelli A, Arba F, Ruggiero M, Piano M, Gabrieli JD, Ros VD, Romano DG, Cavallini A, Salsano G, Panni P, Limbucci N, Caragliano AA, Russo R, Bigliardi G, Milonia L, Semeraro V, Lozupone E, Cirillo L, Clarençon F, Zini A, Broccolini A, Emergent Carotid Artery Stenting Study Group.   +25 more
europepmc   +1 more source

Flexible photocatalytic materials: From substrate engineering to multi‐field synergistic enhancement

FlexMat, EarlyView.
This review examines flexible photocatalytic systems, covering substrate evolution from polymers to biomass, fabrication methods like electrospinning, and key mechanical and optoelectrochemical metrics under deformation. Enhancement strategies are critically discussed, followed by applications in energy conversion, environmental remediation, and ...
Weiqi Wang, Xinrong Zhang, Jing Zhao, Songcan Wang   +3 more
wiley   +1 more source

Endovascular treatment of acute ischemic stroke patients with tandem lesions: antegrade versus retrograde approach. [PDF]

J Neurosurg
Galecio-Castillo M, Abraham M, Farooqui M, Hassan AE, Divani AA, Jumaa MA, Ribo M, Petersen N, Fifi J, Guerrero WR, Malik AM, Siegler JE, Nguyen TN, Sheth SA, Yoo AJ, Linares G, Janjua N, Quispe-Orozco D, Qureshi A, Tekle WG, Ikram A, Zaidi SF, Zevallos CB, Taborda B, Devarajan A, Zhang L, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Rodriguez-Calienes A, Vivanco-Suarez J, Woolfolk K, Mokin M, Yavagal DR, Ortega-Gutierrez S.   +35 more
europepmc   +1 more source

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source

Urinary and Faecal Amino‐Acids as Biomarkers for Colorectal Neoplasia in Lynch Syndrome—A Prospective Longitudinal Study

International Journal of Cancer, EarlyView.
ABSTRACT In Lynch syndrome, colonoscopy surveillance for colorectal cancer (CRC) is burdensome and post‐colonoscopy CRCs still occur. Unlike the faecal immunochemical test (FIT), gut metabolomic alterations including amino‐acids have shown potential as non‐invasive biomarkers for detecting both advanced and non‐advanced sporadic colorectal neoplasia ...
Roza C. M. Opperman, Elsa L. S. A. van Liere, Animesh Acharjee, Sudip Mondal, Eduard A. Struys, Andreas Antoniadis, Jasmijn E. B. de Boer, Shivra R. Siriram, Abdellatif Bakkali, Sofie Bosch, Maarten A. J. M. Jacobs, Jan Jacob Koornstra, Johan P. Kuijvenhoven, Monique E. van Leerdam, Manon C. W. Spaander, Tim G. J. de Meij, Evelien Dekker, Dewkoemar Ramsoekh, Nanne K. H. de Boer   +18 more
wiley   +1 more source

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Safety Outcomes of Antiplatelet Therapy During Endovascular Treatment of Tandem Lesions in Acute Ischemic Stroke Patients. [PDF]

Transl Stroke Res
Farooqui M, Divani AA, Galecio-Castillo M, Hassan AE, Jumaa MA, Ribo M, Abraham M, Petersen N, Fifi J, Guerrero WR, Malik AM, Siegler JE, Nguyen TN, Sheth SA, Yoo AJ, Linares G, Janjua N, Quispe-Orozco D, Ikram A, Tekle WG, Zaidi SF, Zevallos CB, Rizzo F, Barkley T, De Leacy R, Khalife J, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Rodriguez-Calienes A, Vivanco-Suarez J, Turabova C, Mokin M, Yavagal DR, Ortega-Gutierrez S.   +35 more
europepmc   +1 more source

Human Protein Biomarkers Outperform Bacterial Proteins in Colorectal Cancer Detection

International Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) generally develops from precancerous adenomatous lesions, including advanced adenomas (AA), through a sequence of carcinogenic molecular alterations. The composition of the gut microbiota and the fecal proteome is known to differ between individuals with AA and CRC compared to controls, providing opportunities for ...
Roza C. M. Opperman, Sofie Bosch, Alex A. Henneman, Thang V. Pham, Sander R. Piersma, Tim G. J. de Meij, Meike de Wit, Beatriz Carvalho, Remond J. A. Fijneman, Gerrit A. Meijer, Evelien Dekker, Connie R. Jimenez, Nanne K. H. de Boer   +12 more
wiley   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source