Results 101 to 110 of about 627,015 (382)
BioTechniques, 2006 Protein activity and turnover is tightly and dynamically regulated in living cells. Whereas the three-dimensional protein structure is predominantly determined by the amino acid sequence, posttranslational modification (PTM) of proteins modulates their ...
Martin R. Larsen +3 more
doaj +1 more source
GA-Novo: De Novo Peptide Sequencing via Tandem Mass Spectrometry using Genetic Algorithm [PDF]
arXiv, 2019 Proteomics is the large-scale analysis of the proteins. The common method for identifying proteins and characterising their amino acid sequences is to digest the proteins into peptides, analyse the peptides using mass spectrometry and assign the resulting tandem mass spectra (MS/MS) to peptides using database search tools.
arxiv
Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry [PDF]
European Biophysics Journal, 2019 Fourier transform ion cyclotron resonance mass analysers (FT-ICR MS) can offer the highest resolutions and mass accuracies in mass spectrometry. Mass spectra acquired in an FT-ICR MS can yield accurate elemental compositions of all compounds in a complex sample. Fragmentation caused by ion-neutral, ion-electron, or ion-photon interactions leads to more
Maria A. van Agthoven +4 more
openaire +7 more sources
Arthritis Care &Research, EarlyView.Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner +12 more
wiley +1 more source
Determination of Diphenylamine in Gunshot Residue by HPLC-MS/MS
Journal of Forensic Science and Medicine, 2016 A high performance liquid chromatography tandem mass spectrometry/mass spectrometry (HPLC-MS/MS) protocol was developed for the determination of diphenylamine (DPA).
Hongcheng Mei +6 more
doaj +1 more source
Minimizing technical variation during sample preparation prior to label-free quantitative mass spectrometry [PDF]
, 2015 Sample preparation is the crucial starting point to obtain high-quality mass spectrometry data and can be divided into two main steps in a bottom-up proteomics approach: cell/tissue lysis with or without detergents and a(n) (in-solution) digest ...
De Sutter, Petra +6 more
core +2 more sources
Advanced Functional Materials, EarlyView.Graded refractive index (GRI) structures are prepared from the layer‐by‐layer spray coating of the mesoporous SiO2 nanoparticles, showing high solar transparency and thermal emissivity. Under outdoor conditions, after 50 days, the GRI‐coated photovoltaics show on average 6.65 ± 1.48 °C lower than that of the non‐coated references, maintaining 80.9 ± 8 ...
Heesuk Jung +14 more
wiley +1 more source
Journal of Lipid Research, 2003 Sphingolipid activator proteins (saposins A, B, C, and D) are derived from a common precursor protein (prosaposin) and specifically activate in vivo degradation of glycolipids with short carbohydrate chains.
Keiko Tadano-Aritomi +4 more
doaj
Sucrose gradient chromatin enrichment for quantitative proteomics analysis in budding yeast
STAR Protocols, 2021 Summary: Here, we describe a fractionation protocol optimized to quantify changes in relative abundance of the chromatin-bound proteome (chromatome) by tandem mass tag multiplexing-based tandem mass spectrometry. It has been applied to yeast cells before
Kiran Challa +2 more
doaj
Fragmentation trees reloaded [PDF]
arXiv, 2014 Metabolites, small molecules that are involved in cellular reactions, provide a direct functional signature of cellular state. Untargeted metabolomics experiments usually relies on tandem mass spectrometry to identify the thousands of compounds in a biological sample. Today, the vast majority of metabolites remain unknown.
arxiv