Results 181 to 190 of about 423,639 (301)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Analysis of polychlorinated alkanes in food by liquid chromatography-tandem mass spectrometry. [PDF]

Anal Bioanal Chem
Perkons I, Lazdina L, Zacs D.
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Phytochemical Analysis of Veratrum Alkaloids in Medicinal Veratrum Globules Using High-Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry. [PDF]

Biomed Chromatogr
Siegle J, Pietsch J.
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Comparability of Liquid Chromatography Tandem Mass Spectrometry Analysis of Dissolved Organic Matter across Laboratories. [PDF]

Environ Sci Technol
Kalinski JC, Ruiz Brandão da Costa B, Schramm T, Buckett LR, Carlson LT, Coffey NR, Damiani T, Dechent E, Abiead YE, Heuckeroth S, Jennings EK, Kaesler J, Stock NL, Orme AM, Torres RR, Trojahn S, Whelton HL, Yan Y, Aron AT, Boiteau RM, Bull ID, Dorrestein PC, Dang DH, Evershed RP, Gledhill M, Gleixner G, Haas AF, Hansen M, Harder T, Hopmans EC, Ingalls AE, Karst U, Kew W, Kido Soule M, Koch BP, Kujawinski EB, Lechtenfeld OJ, Longnecker K, Pluskal T, Pohnert G, Redman ZC, Rivas-Ubach A, Schmitt-Kopplin P, Singer G, Tebben J, Tomco PL, Ward ND, Aluwihare LI, Simon C, Hawkes J, Petras D.   +50 more
europepmc   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Urine tapentadol quantification in people injecting supratherapeutic doses: Clinical utility and liquid chromatography-tandem mass spectrometry method validation. [PDF]

Indian J Psychiatry
Sharma P, Shivaprakash P, Shukla L, Murthy P.   +3 more
europepmc   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Method Development and Validation of Liquid Chromatography Tandem Mass Spectrometry for SLP-1A6 in Rat Plasma. [PDF]

J Chromatogr Sci
Chen Y, Adebusuyi T, Oppong E, Abraham E, Lawrence YM, Ma J, Liang D, Pham SL, McDonald FE, Danaher A, Wu D, Xie H.   +11 more
europepmc   +1 more source