Results 201 to 210 of about 138,571 (312)

Tandem repeat-induced sexual silencing: A Rid-dependent RNAi mechanism for fungal genome defense via translational repression. [PDF]

Sci Adv
Hou M, Ni Y, Yin J, Wu M, Zhang H, Du Y, Chen S, Zhou Z, Jiang C, Wang Q, Liu H.   +10 more
europepmc   +1 more source

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Mosaicism in Short Tandem Repeat Disorders: A Clinical Perspective. [PDF]

Genes (Basel)
Doss RM, Lopez-Ignacio S, Dischler A, Hiatt L, Dashnow H, Breuss MW, Dias CM.   +6 more
europepmc   +1 more source

Analysis of short tandem repeats linked to polyglutamine diseases from whole-genome sequencing reveals intermediate alleles of HTT associated with an early disease onset in C9orf72 carriers [PDF]

Mathieu Barbier, Thomas Gareau, Agnès Camuzat, Marine Guillaud-Bataille, Susana Boluda, Fabienne Clot, Lara Araktingi, Barbara Borroni, Julie van der Zee, Roberta Ghidoni, Sonia Bellini, Daniela Galimberti, Giacomina Rossi, Benedetta Nacmias, Beatriz De la Casa‐Fages, Pau Pástor, Alexis Brice, Sophie Auriacombe, Serge Belliard, Frédéric Blanc, Stéphanie Bombois, Claire Boutoleau‐Bretonnière, Agnès Camuzat, Mathieu Ceccaldi, Philippe Couratier, Vincent Deramecourt, Mira Didic, Frédérique Etcharry‐Bouyx, Maïté Formaglio, Véronique Golfier, Didier Hannequin, Lucette Lacomblez, Julien Lagarde, Isabelle Le Ber, Richard Levy, Florence Pasquier, Thibaud Lebouvier, Carole Roué-Jagot, Anne Salmon, Marie Sarazin, Christel Thauvin-Robinet, Catherine Thomas-Antérion, Jérémie Pariente, François Sellal, Daisy Rinaldi, Adeline Rollin‐Sillaire, Martine Vercelletto, David Wallon, Morwena Latouche, E. Le Guern, Alexandra Dürr, A. Laquérrière, Rob Moccia, Danielle Seilhean, Victoria Álvarez, Isabelle Le Ber   +55 more
openalex   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Short tandem repeat variants are possibly associated with RNA secondary structure and gene expression. [PDF]

PLoS One
Kinney N, Pathak D, Evans E, Arias P.
europepmc   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions. [PDF]

PLoS Pathog
Ortigas-Vasquez A, Bowen CD, Renner DW, Baigent SJ, Zhang Y, Yao Y, Nair V, Kennedy DA, Szpara ML.   +8 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Emergence and Tandem Repeat-Mediated Elongation of a Translated De Novo Open Reading Frame in Human Oncogenic RNA Gene VPS9D1-AS1 (MYU). [PDF]

Genome Biol Evol
Chou L, Cho ST, Lee J, Laub D, Meyer D, Carter H, Carvunis AR.   +6 more
europepmc   +1 more source