Results 181 to 190 of about 472,632 (203)

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

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Evolution of a Human-Specific Tandem Repeat Associated with ALS

American Journal of Human Genetics, 2020
Nicolas Dupré, Guy A. Rouleau, Aaron D Gitler   +2 more
exaly  

RPTRF: A rapid perfect tandem repeat finder tool for DNA sequences

BioSystems, 2023
Mahmoud Naghibzadeh, Mostafa Nouri-Baygi
exaly  

Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries

Cell, 2018
Beverly L. Davidson, Jennifer E Phillips-Cremins, Flora Tassone   +2 more
exaly  

Human-specific tandem repeat expansion and differential gene expression during primate evolution

Proceedings of the National Academy of Sciences of the United States of America, 2019
Mark J P Chaisson, David Porubsky, Ruiyang Li   +2 more
exaly  

Genetic diversity in the Mycobacterium tuberculosis complex based on variable numbers of tandem DNA repeats

Microbiology (United Kingdom), 1998
Richard Frothingham
exaly  

Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity

Cell, 2018
Chiara Balestrieri, Giorgio Scita, Gabriele Alfarano   +2 more
exaly  

Variation in Short Tandem Repeat sequences —a survey of twelve microsatellite loci for use as forensic identification markers

International Journal of Legal Medicine, 1994
Peter Gill, C P Kimpton, A Urquhart
exaly