Results 1 to 10 of about 397,005 (298)
GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer’s disease [PDF]
Nature CommunicationsGWAS typically focus on SNPs, often excluding complex genetic variants, such as short tandem repeats. Here, we report the results of GWAS analyses systematically assessing the role of short tandem repeats, both imputed and directly genotyped by whole ...
David Gmelin +10 more
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Fish mapping of rdna and novel tandem repeats in Citrus species [PDF]
Comparative CytogeneticsCytogenetic analysis of Citrus Linnaeus, 1753 species is complicated by the small size and morphological similarity of their chromosomes. In this study, we applied the fluorescence in situ hybridization (FISH) method using rDNA probes, as well as newly ...
Yuliya N. Smotrova +3 more
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Characterization of M11-like and OC125-like Monoclonal Antibody Binding to CA125 Tandem Repeats [PDF]
BiosensorsThe CA125 epitope within the MUC16 tandem repeat region is detected via the CA125 II test for ovarian cancer surveillance. This test utilizes the M11 and OC125 antibodies.
Trisha Nair +6 more
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Genome-wide selection inference at short tandem repeats. [PDF]
PLoS GeneticsShort tandem repeats (STRs) comprising repeated sequences of 1-6 bp are one of the largest sources of genetic variation in humans. STRs are known to contribute to a variety of disorders, including Mendelian diseases, complex traits, and cancer.
Bonnie Huang +6 more
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Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions [PDF]
Life Science AllianceWe found that insertions and deletions occur more frequently in longer internal exons and mostly encode structure-less regions, and that half of them are attributable to alterations in tandem repeats.
Keiichi Homma +3 more
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BMC Medical Genomics, 2021 Background Tandem repeats are highly mutable and contribute to the development of human disease by a variety of mechanisms. It is difficult to predict which tandem repeats may cause a disease.
Satomi Mitsuhashi +2 more
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Genomic abundance is not predictive of tandem repeat localization in grass genomes. [PDF]
PLoS ONE, 2017 Highly repetitive regions have historically posed a challenge when investigating sequence variation and content. High-throughput sequencing has enabled researchers to use whole-genome shotgun sequencing to estimate the abundance of repetitive sequence ...
Paul Bilinski +7 more
doaj +1 more source
The Singular Evolution of Olea Genome Structure
Frontiers in Plant Science, 2022 The current view of plant genome evolution proposes that genome size has mainly been determined by polyploidisation and amplification/loss of transposons, with a minor role played by other repeated sequences, such as tandem repeats.
Flavia Mascagni +9 more
doaj +1 more source
Frontiers in Plant Science, 2021 Tandem repeats can occupy a large portion of plant genomes and can either cause or result from chromosomal rearrangements, which are important drivers of dysploidy-mediated karyotype evolution and speciation.
Nomar Espinosa Waminal +3 more
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Assessing the role of tandem repeats in shaping the genomic architecture of great apes. [PDF]
PLoS ONE, 2011 BACKGROUND: Ancestral reconstructions of mammalian genomes have revealed that evolutionary breakpoint regions are clustered in regions that are more prone to break and reorganize.
Marta Farré +4 more
doaj +1 more source