Results 1 to 10 of about 2,331 (69)

Specific Tandem Repeats Are Sufficient for Paramutation-Induced Trans-Generational Silencing [PDF]

PLoS Genetics, 2013
Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles.
Mario Arteaga-Vázquez, Maike Stam, Vicki L Chandler   +2 more
exaly   +2 more sources

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general population

BMC Medical Genomics, 2021
Background Tandem repeats are highly mutable and contribute to the development of human disease by a variety of mechanisms. It is difficult to predict which tandem repeats may cause a disease.
Satomi Mitsuhashi, Martin C. Frith, Naomichi Matsumoto   +2 more
doaj   +1 more source

Genomic abundance is not predictive of tandem repeat localization in grass genomes. [PDF]

PLoS ONE, 2017
Highly repetitive regions have historically posed a challenge when investigating sequence variation and content. High-throughput sequencing has enabled researchers to use whole-genome shotgun sequencing to estimate the abundance of repetitive sequence ...
Paul Bilinski, Yonghua Han, Matthew B Hufford, Anne Lorant, Pingdong Zhang, Matt C Estep, Jiming Jiang, Jeffrey Ross-Ibarra   +7 more
doaj   +1 more source

The Singular Evolution of Olea Genome Structure

Frontiers in Plant Science, 2022
The current view of plant genome evolution proposes that genome size has mainly been determined by polyploidisation and amplification/loss of transposons, with a minor role played by other repeated sequences, such as tandem repeats.
Flavia Mascagni, Elena Barghini, Marilena Ceccarelli, Luciana Baldoni, Carlos Trapero, Carlos Trapero, Concepción Muñoz Díez, Lucia Natali, Andrea Cavallini, Tommaso Giordani   +9 more
doaj   +1 more source

Assessing the role of tandem repeats in shaping the genomic architecture of great apes. [PDF]

PLoS ONE, 2011
BACKGROUND: Ancestral reconstructions of mammalian genomes have revealed that evolutionary breakpoint regions are clustered in regions that are more prone to break and reorganize.
Marta Farré, Montserrat Bosch, Francesc López-Giráldez, Montserrat Ponsà, Aurora Ruiz-Herrera   +4 more
doaj   +1 more source

Chromosomal Mapping of Tandem Repeats Revealed Massive Chromosomal Rearrangements and Insights Into Senna tora Dysploidy

Frontiers in Plant Science, 2021
Tandem repeats can occupy a large portion of plant genomes and can either cause or result from chromosomal rearrangements, which are important drivers of dysploidy-mediated karyotype evolution and speciation.
Nomar Espinosa Waminal, Remnyl Joyce Pellerin, Sang-Ho Kang, Hyun Hee Kim   +3 more
doaj   +1 more source

Development and validation of LAMP primer sets for rapid identification of Aspergillus fumigatus carrying the cyp51A TR46 azole resistance gene

Scientific Reports, 2021
Infections due to triazole-resistant Aspergillus fumigatus are increasingly reported worldwide and are associated with treatment failure and mortality. The principal class of azole-resistant isolates is characterized by tandem repeats of 34 bp or 46 bp ...
Plinio Trabasso, Tetsuhiro Matsuzawa, Teppei Arai, Daisuke Hagiwara, Yuzuru Mikami, Maria Luiza Moretti, Akira Watanabe   +6 more
doaj   +1 more source

Comparative Geometrical Analysis of Leucine-Rich Repeat Structures in the Nod-Like and Toll-Like Receptors in Vertebrate Innate Immunity

Biomolecules, 2015
The NOD-like receptors (NLRs) and Toll-like receptors (TLRs) are pattern recognition receptors that are involved in the innate, pathogen pattern recognition system.
Norio Matsushima, Hiroki Miyashita, Purevjav Enkhbayar, Robert H. Kretsinger   +3 more
doaj   +1 more source

Insight into role of selection in the evolution of polyglutamine tracts in humans. [PDF]

PLoS ONE, 2012
Glutamine tandem repeats are common in eukaryotic proteins. Although some studies have proposed that replication slippage plays an important role in shaping these repeats, the role of natural selection in glutamine tandem repeat evolution is somewhat ...
Hongwei Li, Jing Liu, Keliang Wu, Yuan Chen   +3 more
doaj   +1 more source

NanoSatellite: accurate characterization of expanded tandem repeat length and sequence through whole genome long-read sequencing on PromethION

Genome Biology, 2019
Technological limitations have hindered the large-scale genetic investigation of tandem repeats in disease. We show that long-read sequencing with a single Oxford Nanopore Technologies PromethION flow cell per individual achieves 30× human genome ...
Arne De Roeck, Wouter De Coster, Liene Bossaerts, Rita Cacace, Tim De Pooter, Jasper Van Dongen, Svenn D’Hert, Peter De Rijk, Mojca Strazisar, Christine Van Broeckhoven, Kristel Sleegers   +10 more
doaj   +1 more source