Results 1 to 10 of about 199,782 (293)

Functional and immunological relevance of Anaplasma marginale major surface protein 1a sequence and structural analysis. [PDF]

PLoS ONE, 2013
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A.
Alejandro Cabezas-Cruz, Lygia M F Passos, Katarzyna Lis, Rachel Kenneil, James J Valdés, Joana Ferrolho, Miray Tonk, Anna E Pohl, Libor Grubhoffer, Erich Zweygarth, Varda Shkap, Mucio F B Ribeiro, Agustín Estrada-Peña, Katherine M Kocan, José de la Fuente   +14 more
doaj   +11 more sources

Diversity in coding tandem repeats in related Neisseria spp. [PDF]

BMC Microbiology, 2003
Background Tandem repeats contained within coding regions can mediate phase variation when the repeated units change the reading frame of the coding sequence in a copy number dependent manner.
Saunders Nigel J, Snyder Lori AS, Jordan Philip   +2 more
doaj   +5 more sources

Characterization of M11-like and OC125-like Monoclonal Antibody Binding to CA125 Tandem Repeats [PDF]

Biosensors
The CA125 epitope within the MUC16 tandem repeat region is detected via the CA125 II test for ovarian cancer surveillance. This test utilizes the M11 and OC125 antibodies.
Trisha Nair, Caitlin R. McEntee, Chien-Wei Wang, Anubhuti Srivastava, Jane C. March, Eliza K. Hanson, Rebecca J. Whelan   +6 more
doaj   +2 more sources

Analysis of the largest tandemly repeated DNA families in the human genome [PDF]

BMC Genomics, 2008
Background Tandemly Repeated DNA represents a large portion of the human genome, and accounts for a significant amount of copy number variation. Here we present a genome wide analysis of the largest tandem repeats found in the human genome sequence ...
Jin Xiaoping, Lescale Chloe, Guillem Flavia, Hasson Dan, Warburton Peter E, Abrusan Gyorgy   +5 more
doaj   +4 more sources

Genome-wide selection inference at short tandem repeats. [PDF]

PLoS Genetics
Short tandem repeats (STRs) comprising repeated sequences of 1-6 bp are one of the largest sources of genetic variation in humans. STRs are known to contribute to a variety of disorders, including Mendelian diseases, complex traits, and cancer.
Bonnie Huang, Arun Durvasula, Nima Mousavi, Helyaneh Ziaei-Jam, Mikhail Maksimov, Kirk E Lohmueller, Melissa Gymrek   +6 more
doaj   +2 more sources

TRFill: synergistic use of HiFi and Hi-C sequencing enables accurate assembly of tandem repeats for population-level analysis [PDF]

Genome Biology
The highly repetitive content of eukaryotic genomes, including long tandem repeats, segmental duplications, and centromeres, makes haplotype-resolved genome assembly hard. Repeat sequences introduce gaps or mis-joins in the assemblies.
Huaming Wen, Jinbao Yang, Xianjia Zhao, Xingbin Wang, Jiawei Lei, Yanchun Li, Wenjie Du, Dongxi Li, Yun Xu, Stefano Lonardi, Weihua Pan   +10 more
doaj   +2 more sources

Native functions of short tandem repeats

eLife, 2023
Over a third of the human genome is comprised of repetitive sequences, including more than a million short tandem repeats (STRs). While studies of the pathologic consequences of repeat expansions that cause syndromic human diseases are extensive, the ...
Shannon E Wright, Peter K Todd
doaj   +3 more sources

Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions [PDF]

Life Science Alliance
We found that insertions and deletions occur more frequently in longer internal exons and mostly encode structure-less regions, and that half of them are attributable to alterations in tandem repeats.
Keiichi Homma, Hiroto Anbo, Motonori Ota, Satoshi Fukuchi   +3 more
doaj   +2 more sources

Structured Tandem Repeats in Protein Interactions. [PDF]

Int J Mol Sci
Tandem repeats (TRs) in protein sequences are consecutive, highly similar sequence motifs. Some types of TRs fold into structural units that pack together in ensembles, forming either an (open) elongated domain or a (closed) propeller, where the last unit of the ensemble packs against the first one.
Mac Donagh J, Marchesini A, Spiga A, Fallico MJ, Arrías PN, Monzon AM, Vagiona AC, Gonçalves-Kulik M, Mier P, Andrade-Navarro MA.   +9 more
europepmc   +4 more sources

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general population

BMC Medical Genomics, 2021
Background Tandem repeats are highly mutable and contribute to the development of human disease by a variety of mechanisms. It is difficult to predict which tandem repeats may cause a disease.
Satomi Mitsuhashi, Martin C. Frith, Naomichi Matsumoto   +2 more
doaj   +1 more source