Results 1 to 10 of about 106,785 (200)

GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease. [PDF]

Nat Commun
GWAS typically focus on SNPs, often excluding complex genetic variants, such as short tandem repeats. Here, we report the results of GWAS analyses systematically assessing the role of short tandem repeats, both imputed and directly genotyped by whole ...
Gmelin D, Ohlei O, Aslam MM, Junge MP, Parkkinen L, Mullin K, Prokopenko D, Lill CM, Tanzi RE, Dobricic V, Bertram L.   +10 more
europepmc   +2 more sources

Chromosomal Mapping of Tandem Repeats Revealed Massive Chromosomal Rearrangements and Insights Into Senna tora Dysploidy

Frontiers in Plant Science, 2021
Tandem repeats can occupy a large portion of plant genomes and can either cause or result from chromosomal rearrangements, which are important drivers of dysploidy-mediated karyotype evolution and speciation.
Nomar Espinosa Waminal, Sang-Ho Kang, Hyun Hee Kim   +2 more
exaly   +3 more sources

Specific Tandem Repeats Are Sufficient for Paramutation-Induced Trans-Generational Silencing [PDF]

PLoS Genetics, 2013
Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles.
Lyudmila Sidorenko, Maike Stam, Mario A Arteaga-Vázquez   +2 more
exaly   +2 more sources

Characterization of M11-like and OC125-like Monoclonal Antibody Binding to CA125 Tandem Repeats. [PDF]

Biosensors (Basel)
The CA125 epitope within the MUC16 tandem repeat region is detected via the CA125 II test for ovarian cancer surveillance. This test utilizes the M11 and OC125 antibodies.
Nair T, McEntee CR, Wang CW, Srivastava A, March JC, Hanson EK, Whelan RJ.   +6 more
europepmc   +2 more sources

Genome-wide selection inference at short tandem repeats. [PDF]

PLoS Genet
Short tandem repeats (STRs) comprising repeated sequences of 1-6 bp are one of the largest sources of genetic variation in humans. STRs are known to contribute to a variety of disorders, including Mendelian diseases, complex traits, and cancer.
Huang B, Durvasula A, Mousavi N, Ziaei-Jam H, Maksimov M, Lohmueller KE, Gymrek M.   +6 more
europepmc   +2 more sources

TRFill: synergistic use of HiFi and Hi-C sequencing enables accurate assembly of tandem repeats for population-level analysis. [PDF]

Genome Biol
The highly repetitive content of eukaryotic genomes, including long tandem repeats, segmental duplications, and centromeres, makes haplotype-resolved genome assembly hard. Repeat sequences introduce gaps or mis-joins in the assemblies.
Wen H, Yang J, Zhao X, Wang X, Lei J, Li Y, Du W, Li D, Xu Y, Lonardi S, Pan W.   +10 more
europepmc   +2 more sources

Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions. [PDF]

Life Sci Alliance
We found that insertions and deletions occur more frequently in longer internal exons and mostly encode structure-less regions, and that half of them are attributable to alterations in tandem repeats.
Homma K, Anbo H, Ota M, Fukuchi S.
europepmc   +2 more sources

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general population

BMC Medical Genomics, 2021
Background Tandem repeats are highly mutable and contribute to the development of human disease by a variety of mechanisms. It is difficult to predict which tandem repeats may cause a disease.
Satomi Mitsuhashi, Martin C. Frith, Naomichi Matsumoto   +2 more
doaj   +1 more source

Genomic abundance is not predictive of tandem repeat localization in grass genomes. [PDF]

PLoS ONE, 2017
Highly repetitive regions have historically posed a challenge when investigating sequence variation and content. High-throughput sequencing has enabled researchers to use whole-genome shotgun sequencing to estimate the abundance of repetitive sequence ...
Paul Bilinski, Yonghua Han, Matthew B Hufford, Anne Lorant, Pingdong Zhang, Matt C Estep, Jiming Jiang, Jeffrey Ross-Ibarra   +7 more
doaj   +1 more source

The Singular Evolution of Olea Genome Structure

Frontiers in Plant Science, 2022
The current view of plant genome evolution proposes that genome size has mainly been determined by polyploidisation and amplification/loss of transposons, with a minor role played by other repeated sequences, such as tandem repeats.
Flavia Mascagni, Elena Barghini, Marilena Ceccarelli, Luciana Baldoni, Carlos Trapero, Carlos Trapero, Concepción Muñoz Díez, Lucia Natali, Andrea Cavallini, Tommaso Giordani   +9 more
doaj   +1 more source