Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases
Non-coding RNA, 2020 Nuclear bodies are membraneless, phase-separated compartments that concentrate specific proteins and RNAs in the nucleus. They are believed to serve as sites for the modification, sequestration, and storage of specific factors, and to act as ...
Tetsuro Hirose +2 more
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Efficient Synthesis of the Lewis A Tandem Repeat
Molecules, 2016 The convergent synthesis of the Lewis A (Lea) tandem repeat is described. The Lea tandem repeat is a carbohydrate ligand for a mannose binding protein that shows potent inhibitory activity against carcinoma growth.
, Makoto Kiso, Akihiro Imamura
exaly +3 more sources
Squid-Inspired Tandem Repeat Proteins: Functional Fibers and Films
Frontiers in Chemistry, 2019 Production of repetitive polypeptides that comprise one or more tandem copies of a single unit with distinct amorphous and ordered regions have been an interest for the last couple of decades.
Abdon Pena-Francesch +2 more
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Expanding the repertoire of human tandem repeat RNA-binding proteins.
PLoS ONE, 2023 Protein regions consisting of arrays of tandem repeats are known to bind other molecular partners, including nucleic acid molecules. Although the interactions between repeat proteins and DNA are already widely explored, studies characterising tandem ...
Agustín Ormazábal +6 more
doaj +1 more source
BMC Medical Genomics, 2021 Background Tandem repeats are highly mutable and contribute to the development of human disease by a variety of mechanisms. It is difficult to predict which tandem repeats may cause a disease.
Satomi Mitsuhashi +2 more
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5meCpG epigenetic marks neighboring a primate-conserved core promoter short tandem repeat indicate X-chromosome inactivation. [PDF]
PLoS ONE, 2014 X-chromosome inactivation (XCI) is the epigenetic transcriptional silencing of an X-chromosome during the early stages of embryonic development in female eutherian mammals.
Filipe Brum Machado +12 more
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The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice
Breast Cancer: Basic and Clinical Research, 2008 Background Though the importance of the transmembrane mucin MUC1 in mammary oncogenesis has long been recognized, the relative contributions of the cytoplasmic tail and tandem repeat domains are poorly understood. Methods To address this, mouse models of
Christine L. Hattrup +6 more
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Digital genotyping of macrosatellites and multicopy genes reveals novel biological functions associated with copy number variation of large tandem repeats. [PDF]
PLoS Genetics, 2014 Tandem repeats are common in eukaryotic genomes, but due to difficulties in assaying them remain poorly studied. Here, we demonstrate the utility of Nanostring technology as a targeted approach to perform accurate measurement of tandem repeats even at ...
Manisha Brahmachary +6 more
doaj +1 more source
Global Repeat Map (GRM) Application: Finding All DNA Tandem Repeat Units
Algorithms, 2022 Tandem repeats (TRs) are important components of eukaryotic genomes; they have both structural and functional roles: (i) they form essential chromosome structures such as centromeres and telomeres; (ii) they modify chromatin structure and affect ...
Matko Glunčić +3 more
doaj +1 more source
Data in Brief, 2019 The datasets included sequences of a control region from Myotis bat mitogenomes. The control region (1706–2005 bp) of the Myotis mitogenomes was divided into three domains similar to that of other mammals, which included the common conserved blocks (ETAS
Md M. Rahman +2 more
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