Results 1 to 10 of about 587,185 (300)

A comprehensive tandem repeat catalog of the human genome [PDF]

Nature Communications
With the increasing availability of long-read sequencing data, high-quality human genome assemblies, and software for fully characterizing tandem repeats, genome-wide genotyping of tandem repeat loci on a population scale is becoming more feasible.
Readman Chiu, Indhu-Shree Rajan-Babu, Jan M. Friedman, Inanc Birol   +3 more
doaj   +3 more sources

Expanding the repertoire of human tandem repeat RNA-binding proteins. [PDF]

PLoS ONE, 2023
Protein regions consisting of arrays of tandem repeats are known to bind other molecular partners, including nucleic acid molecules. Although the interactions between repeat proteins and DNA are already widely explored, studies characterising tandem ...
Agustín Ormazábal, Matías Sebastián Carletti, Tadeo Enrique Saldaño, Martín Gonzalez Buitron, Julia Marchetti, Nicolas Palopoli, Alex Bateman   +6 more
doaj   +2 more sources

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general population

BMC Medical Genomics, 2021
Background Tandem repeats are highly mutable and contribute to the development of human disease by a variety of mechanisms. It is difficult to predict which tandem repeats may cause a disease.
Satomi Mitsuhashi, Martin C. Frith, Naomichi Matsumoto   +2 more
doaj   +1 more source

5meCpG epigenetic marks neighboring a primate-conserved core promoter short tandem repeat indicate X-chromosome inactivation. [PDF]

PLoS ONE, 2014
X-chromosome inactivation (XCI) is the epigenetic transcriptional silencing of an X-chromosome during the early stages of embryonic development in female eutherian mammals.
Filipe Brum Machado, Fabricio Brum Machado, Milena Amendro Faria, Viviane Lamim Lovatel, Antonio Francisco Alves da Silva, Claudia Pamela Radic, Carlos Daniel De Brasi, Álvaro Fabricio Lopes Rios, Susana Marina Chuva de Sousa Lopes, Leonardo Serafim da Silveira, Carlos Ramon Ruiz-Miranda, Ester Silveira Ramos, Enrique Medina-Acosta   +12 more
doaj   +1 more source

The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice

Breast Cancer: Basic and Clinical Research, 2008
Background Though the importance of the transmembrane mucin MUC1 in mammary oncogenesis has long been recognized, the relative contributions of the cytoplasmic tail and tandem repeat domains are poorly understood. Methods To address this, mouse models of
Christine L. Hattrup, Judy M. Bradley, Kari L. Kotlarczyk, Cathy S. Madsen, Joseph G. Hentz, Ronald J. Marler, Sandra J. Gendler   +6 more
doaj   +2 more sources

Digital genotyping of macrosatellites and multicopy genes reveals novel biological functions associated with copy number variation of large tandem repeats. [PDF]

PLoS Genetics, 2014
Tandem repeats are common in eukaryotic genomes, but due to difficulties in assaying them remain poorly studied. Here, we demonstrate the utility of Nanostring technology as a targeted approach to perform accurate measurement of tandem repeats even at ...
Manisha Brahmachary, Audrey Guilmatre, Javier Quilez, Dan Hasson, Christelle Borel, Peter Warburton, Andrew J Sharp   +6 more
doaj   +1 more source

Global Repeat Map (GRM) Application: Finding All DNA Tandem Repeat Units

Algorithms, 2022
Tandem repeats (TRs) are important components of eukaryotic genomes; they have both structural and functional roles: (i) they form essential chromosome structures such as centromeres and telomeres; (ii) they modify chromatin structure and affect ...
Matko Glunčić, Ines Vlahović, Leo Mršić, Vladimir Paar   +3 more
doaj   +1 more source

Structural characteristics of a mitochondrial control region from Myotis bat (Vespertilionidae) mitogenomes based on sequence datasets

Data in Brief, 2019
The datasets included sequences of a control region from Myotis bat mitogenomes. The control region (1706–2005 bp) of the Myotis mitogenomes was divided into three domains similar to that of other mammals, which included the common conserved blocks (ETAS
Md M. Rahman, Kwang B. Yoon, Yung C. Park   +2 more
doaj   +1 more source

Mapping the landscape of tandem repeat variability by targeted long read single molecule sequencing in familial X-linked intellectual disability

BMC Medical Genomics, 2018
Background The etiology of more than half of all patients with X-linked intellectual disability remains elusive, despite array-based comparative genomic hybridization, whole exome or genome sequencing.
Alena Zablotskaya, Hilde Van Esch, Kevin J. Verstrepen, Guy Froyen, Joris R. Vermeesch   +4 more
doaj   +1 more source

Microsatellite Stability in STR Analysis Aspergillus fumigatus Depends on Number of Repeat Units

Frontiers in Cellular and Infection Microbiology, 2019
More than a decade ago a short tandem repeat-based typing method was developed for the fungus Aspergillus fumigatus. This STRAf assay is based on the analysis of nine short tandem repeat markers.
Theun de Groot, Jacques F. Meis, Jacques F. Meis, Jacques F. Meis   +3 more
doaj   +1 more source