Results 31 to 40 of about 312,877 (298)

LEPStr: A database for Mycobacterium leprae short tandem repeats

Informatics in Medicine Unlocked, 2020
Short tandem repeats are short arrays of nucleotide sequences, and they have vital roles in many biological processes, including modulation of transcription, enhancement of gene expression, adaptation to a particular environment, and link to autosomal ...
Partha Sarathi Mohanty, Dimple Saikia, Siddhant Kalra, Farah Naaz, Avi Kumar Bansal, Harpreet Singh Pawar, Keshar Kunja Mohanty, Sandeep Sharma, Manjula Singh, Shripad A. Patil   +9 more
doaj   +1 more source

ClassTR: Classifying Within-Host Heterogeneity Based on Tandem Repeats with Application to Mycobacterium tuberculosis Infections. [PDF]

, 2015
Genomic tools have revealed genetically diverse pathogens within some hosts. Within-host pathogen diversity, which we refer to as "complex infection", is increasingly recognized as a determinant of treatment outcome for infections like tuberculosis ...
Chindelevitch, L, Cohen, T, Colijn, C, Moodley, P, Wilson, D   +4 more
core   +3 more sources

Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo [PDF]

, 2016
Ribonucleotides are the most abundant non-canonical component of yeast genomic DNA and their persistence is associated with a distinctive mutation signature characterized by deletion of a single repeat unit from a short tandem repeat.
Burgers, Peter M, Cho, Jang-Eun, Huang, Shar-yin N, Jinks-Robertson, Sue, Pommier, Yves, Shuman, Stewart   +5 more
core   +2 more sources

Genetic diversity at the FMR1 locus in the Indonesian population [PDF]

, 2000
We report an analysis of allelic diversity at short tandem repeat polymorphisms within the fragile XA locus in 1069 male volunteers from twelve Indonesian sub-populations.
Buckley, Michael F, Faradz, Sultana M.H., Holden, J J A, Jenkins , M, Leggo, J, Leigh, D A, Pattiiha, M Z   +6 more
core   +1 more source

NanoSatellite: accurate characterization of expanded tandem repeat length and sequence through whole genome long-read sequencing on PromethION

Genome Biology, 2019
Technological limitations have hindered the large-scale genetic investigation of tandem repeats in disease. We show that long-read sequencing with a single Oxford Nanopore Technologies PromethION flow cell per individual achieves 30× human genome ...
Arne De Roeck, Wouter De Coster, Liene Bossaerts, Rita Cacace, Tim De Pooter, Jasper Van Dongen, Svenn D’Hert, Peter De Rijk, Mojca Strazisar, Christine Van Broeckhoven, Kristel Sleegers   +10 more
doaj   +1 more source

Rediscovering tandem repeat variation in schizophrenia: challenges and opportunities

Translational Psychiatry, 2023
Tandem repeats (TRs) are prevalent throughout the genome, constituting at least 3% of the genome, and often highly polymorphic. The high mutation rate of TRs, which can be orders of magnitude higher than single-nucleotide polymorphisms and indels ...
Rebecca Birnbaum
doaj   +1 more source

Tandem repeats of the 5′ flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression

Biochemistry and Biophysics Reports, 2019
MUC5AC is a well-known gastric differentiation marker, which has been frequently used for the classification of stomach cancer. However, the molecular mechanism of regulation of MUC5AC expression remains to be elucidated.
Natsuko Kageyama-Yahara, Nobutake Yamamichi, Yu Takahashi, Chihiro Takeuchi, Yuta Matsumoto, Yoshiki Sakaguchi, Kazuhiko Koike   +6 more
doaj   +1 more source

Insertion of ten amino acids into 13S globulin zero-repeat subunit improves trypsin digestibility in common buckwheat (Fagopyrum esculentum Moench) seeds

Food Chemistry: Molecular Sciences, 2023
The 13S globulin zero-repeat subunit is resistant to trypsin and may have higher allergenicity than the 1–6 tandem repeat subunits in common buckwheat (Fagopyrum esculentum Moench).
Takeyuki Okada, Fakhrul Islam Monshi, Syuto Kudo, Tomoyuki Katsube-Tanaka   +3 more
doaj   +1 more source

Genetic Diversity and Genotype Distribution of Erwinia amylovora in Korea [PDF]

The Plant Pathology Journal
Erwinia amylovora, first identified in 1793 in Hudson Valley (New York, USA), has a genome size of 3.7–4.0 Mb. E. amylovora bacterial strains are classified based on the infecting hosts: the Amygdaloideae-infecting (AI) group, targeting apple and pear ...
Hyeonheui Ham, Se-Weon Lee, Yong Hwan Lee   +2 more
doaj   +1 more source

Gene–Environment Interactions in Repeat Expansion Diseases: Mechanisms of Environmentally Induced Repeat Instability

Biomedicines, 2023
Short tandem repeats (STRs) are units of 1–6 base pairs that occur in tandem repetition to form a repeat tract. STRs exhibit repeat instability, which generates expansions or contractions of the repeat tract.
Stephanie Calluori, Rebecca Stark, Brandon L. Pearson   +2 more
doaj   +1 more source