Results 51 to 60 of about 587,185 (300)

Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing. [PDF]

PLoS Genetics, 2013
Paramutation is a well-studied epigenetic phenomenon in which trans communication between two different alleles leads to meiotically heritable transcriptional silencing of one of the alleles.
Christiane L Belele, Lyudmila Sidorenko, Maike Stam, Rechien Bader, Mario A Arteaga-Vazquez, Vicki L Chandler   +5 more
doaj   +1 more source

Immune activation by a multigene family of lectins with variable tandem repeats in oriental river prawn (Macrobrachium nipponense) [PDF]

Open Biology, 2020
Genomic regions with repeated sequences are unstable and prone to rapid DNA diversification. However, the role of tandem repeats within the coding region is not fully characterized.
Ying Huang, Xin Huang, Xuming Zhou, Jialin Wang, Ruidong Zhang, Futong Ma, Kaiqiang Wang, Zhuoxing Zhang, Xiaoling Dai, Xueying Cao, Chao Zhang, Keke Han, Qian Ren   +12 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

TRsv: simultaneous detection of tandem repeat variations, structural variations, and short indels using long read sequencing data

Genome Biology
Tandem repeat copy number variations (TR-CNVs), structural variations (SVs), and short indels have been responsible for many diseases and traits, but no tools exist to distinguish and detect these variants.
Shunichi Kosugi, Chikashi Terao
doaj   +1 more source

Estimation of duplication history under a stochastic model for tandem repeats

BMC Bioinformatics, 2019
Background Tandem repeat sequences are common in the genomes of many organisms and are known to cause important phenomena such as gene silencing and rapid morphological changes. Due to the presence of multiple copies of the same pattern in tandem repeats
Farzad Farnoud, Moshe Schwartz, Jehoshua Bruck   +2 more
doaj   +1 more source

Tandem-repeat protein domains across the tree of life [PDF]

PeerJ, 2015
Tandem-repeat protein domains, composed of repeated units of conserved stretches of 20–40 amino acids, are required for a wide array of biological functions.
Kristin K. Jernigan, Seth R. Bordenstein
doaj   +2 more sources

Linear time algorithms for finding and representing all the tandem repeats in a string [PDF]

, 2004
Gusfield D, Stoye J. Linear time algorithms for finding and representing all the tandem repeats in a string. Journal of computer and system sciences. 2004;69(4):525-546.A tandem repeat (or square) is a string [alpha][alpha], where [alpha] is a non-empty ...
Stoye, Jens, Stoye, Jens ; https://orcid.org/, Gusfield, Dan   +2 more
core   +1 more source

Distinctive tandem repeat region mutation histories.

, 2021
Violin plots representing the distribution of m or d in tandem repeat regions in the DNA derived from blood cells for patients with different cancer types.
Siddharth Jain (267351), Jehoshua Bruck (6309647), Netanel Raviv (11408504), Bijan Mazaheri (11408501)   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Integrated multiple sequence alignment [PDF]

, 2005
Sammeth M. Integrated multiple sequence alignment. Bielefeld (Germany): Bielefeld University; 2005.The thesis presents enhancements for automated and manual multiple sequence alignment: existing alignment algorithms are made more easily accessible and ...
Sammeth, Michael
core