Results 251 to 260 of about 138,571 (312)

The evolution of tandem repeat sequences under partial selfing and different modes of selection

Sudbrack V, Mullon C.
europepmc   +1 more source

Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer's disease. [PDF]

Nat Commun
Guo MH, Lee WP, Vardarajan B, Schellenberg GD, Phillips-Cremins JE.   +4 more
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Reanalysis of Next-Generation Sequencing Data to Detect Tandem Repeat Expansions in 1,106 Czech Probands With Neurologic Disease. [PDF]

Neurol Genet
Musilova A, Lassuthova P, Uhrova Meszarosova A, Straka B, Krejcikova J, Berounska A, Vlckova M, Musova Z, Safka Brozkova D.   +8 more
europepmc   +1 more source

Enhanced discrimination of <i>Clostridioides difficile</i> transmission using whole-genome sequencing and <i>in silico</i> multi-locus variable number tandem repeat analysis. [PDF]

Microbiol Spectr
Sundermann AJ, Mills EG, Rangachar Srinivasa V, Griffith MP, Ereifej D, Waggle KD, Raabe NJ, Snyder GM, Van Tyne D, Pless LL, Harrison LH.   +10 more
europepmc   +1 more source

Evolutionary insights from the mitochondrial genomes of invasive scale insects (Hemiptera: Coccomorpha): large-scale transfer RNA gene truncations and tandem repeat-driven intraspecific gene rearrangements. [PDF]

BMC Genomics
Ye F, Zhou JY, Li ZQ.
europepmc   +1 more source

A PDZ tandem repeat folds and unfolds via different pathways. [PDF]

Protein Sci
Pennacchietti V, di Matteo S, Pagano L, Toplek FB, Stegani B, Toto A, Toso J, Puglisi E, Capelli R, Di Felice M, Malagrinò F, Camilloni C, Gianni S.   +12 more
europepmc   +1 more source

Uterine teratoma and the role of short-tandem repeat genotyping in understanding origins. [PDF]

Gynecol Oncol Rep
AlAshqar A, Kadam Maruthi V, Abi-Raad R, Greenman M, Hui P, Ratner E, Altwerger G, Santin A, Andikyan V.   +8 more
europepmc   +1 more source