Results 231 to 240 of about 312,877 (298)

Identification of Proteins Associated with Stably Integrated Maize <i>b1</i> Tandem Repeat Transgene Chromatin. [PDF]

Plants (Basel)
Lynn JS, Koirtyohann KM, Gebreab YB, Edwards J, McGinnis KM.   +4 more
europepmc   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Enrichment of tandem repeat element variants near CHD genes identified by short- and long-read genome sequencing. [PDF]

BMC Med Genomics
Suresh A, Morton SU, Quiat D, DePalma SR, Gorham JM, Brueckner M, Tristani-Firouzi M, Gelb BD, Seidman JG, Seidman CE, Pediatric Cardiac Genomics Consortium.   +10 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Human Milk Oligosaccharides Multivalently Presented on Defined Synthetic Neo-Glycoproteins Are Nanomolar Ligands of Tandem-Repeat Galectins. [PDF]

Biomacromolecules
Červený J, Heine V, Hovorková M, Brož P, Filipová E, Kulik N, Hubálek M, Cvačka J, Petrásková L, Florencio-Zabaleta M, Delgado S, Pelantová H, Bosáková Z, Elling L, Jiménez-Barbero J, Ardá A, Křen V, Bojarová P.   +17 more
europepmc   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Genome-wide profiling of short tandem repeat somatic instability reveals associations with age, sex and brain-related traits

Hu J, Mantey R, Guo H, Sidky AM, Touhidinia M, Butt T, Sobhani R, Estrada S, Haendler K, Zhao S, Shang X, De Domenico E, Beyer MD, Breteler MMB, Aziz NA.   +14 more
europepmc   +1 more source

Unravelling tandem repeat-mediated mutagenesis drive rapid diversification of KPC enzymes: emergence of bla_KPC-263 and enhanced resistance to ceftazidime-avibactam. [PDF]

EBioMedicine
Ye H, Liu R, Shen J, Yang W, Hu T, Liu X, Wang K, Gong L, Xu H, Zhu J, Zheng Z, Zheng B.   +11 more
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

The evolution of tandem repeat sequences under partial selfing and different modes of selection

Sudbrack V, Mullon C.
europepmc   +1 more source