Results 101 to 110 of about 166,443 (290)
Advanced Science, EarlyView.Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa +11 more
wiley +1 more source
Advanced Science, EarlyView.Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao +5 more
wiley +1 more source
Rethinking rehabilitation: socio-ecology of tanks and water harvesting in Rajasthan, North-west India [PDF]
In the arid and semi- arid Indian state of Rajasthan, tanks and ponds have been a mainstay of rural communities for centuries. There are over 4600 large minor irrigation tanks, plus numerous johads, bandhs and pals (small water harvesting structures ...
Raju, K. Vengama, Shah, Tushaar
core
Advanced Science, EarlyView.Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin +6 more
wiley +1 more source
Broń precyzyjna a czołgi – zagrożenia dla pojazdów pancernych na współczesnym polu walk [PDF]
Przegląd GeopolitycznyThe aim of the article is to discuss the threat to tanks on the contemporary battlefield posed by modern precision anti-tank weapons, illustrated through examples such as kamikaze drones, loitering munitions and guided anti-tank missiles.
Patryk Laskowski
doaj
Developing Soft Interconnected Microchannel Network for 2D Skin‐Like Actuator
Advanced Science, EarlyView.A soft interconnected network of microchannels is proposed to develop new pneumatic actuators for future bio‐inspired soft robots. Simultaneous stimulation of this network generates regional asymmetric strains in walls of microchannels whose interaction across the entire surface leads to bending curvatures in multidimensions.
John Noee +4 more
wiley +1 more source
Advanced Science, EarlyView.Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li +11 more
wiley +1 more source
Advanced Science, EarlyView.Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang +6 more
wiley +1 more source
Advanced Science, EarlyView.In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye +9 more
wiley +1 more source