Frontiers in Cell and Developmental BiologyAmyotrophic lateral sclerosis (ALS) is a major neurodegenerative disease for which there is currently no curative treatment. The blood-brain barrier (BBB), multiple physiological functions formed by mainly specialized brain microvascular endothelial ...
Kinya Matsuo +10 more
semanticscholar +1 more source
Transcriptome and proteome analysis of tyrosine Kinase inhibitor treated canine mast cell tumour cells identifies potentially kit signaling-dependent genes. [PDF]
, 2012 Background Canine mast cell tumor proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor. Inhibitors of the KIT tyrosine kinase have recently been introduced and successfully applied as a therapeutic agent for this ...
Bondzio, Angelika +8 more
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MOLECULAR STRUCTURE OF AMYOTROPHIC LATERAL SCLEROSIS IN RUSSIAN POPULATION
Нервно-мышечные болезни, 2017 Materials and methods. 285 Russian patients with amyotrophic lateral sclerosis (ALS) including 260 patients with a sporadic form and 25 with a familial form were examined for mutations in SOD1, C9orf72, TARDBP, ANG and other genes and the presence of ...
N. Yu. Abramycheva +5 more
doaj +1 more source
Clinical phenotypes and radiological findings in frontotemporal dementia related to TARDBP mutations
Journal of Neurology, 2014 It has been shown that different genes could be associated with distinctive clinical and radiological phenotypes of FTD. TARDBP gene has been described worldwide in few cases of FTD so its phenotype is still unclear. The objective is to study the clinical and radiological characteristics of TARDBP-related FTD.
G. Floris +13 more
openaire +4 more sources
A context-based ABC model for literature-based discovery.
PLoS ONE, 2019 BackgroundIn the literature-based discovery, considerable research has been done based on the ABC model developed by Swanson. ABC model hypothesizes that there is a meaningful relation between entity A extracted from document set 1 and entity C extracted
Yong Hwan Kim, Min Song
doaj +1 more source
Motor neuron differentiation of iPSCs obtained from peripheral blood of a mutant TARDBP ALS patient
Stem Cell Research, 2018 Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease, mainly affecting the motor neurons (MNs) and without effective therapy. Drug screening is hampered by the lack of satisfactory experimental and pre-clinical models.
Patrizia Bossolasco +5 more
doaj +1 more source
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43 [PDF]
, 2019 Aneesh Donde +10 more
openalex +1 more source
Mouse model of amyotrophic lateral sclerosis (ALS) caused by partial loss of TAR DNA binding protein 43 (Tdp-43; Tardbp) function [PDF]
, 2014 openalex +1 more source
Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models [PDF]
, 2021 Anny Devoy +28 more
openalex +1 more source
Estudio del metabolismo de la glucosa en pacientes con esclerosis lateral amiotrófica [PDF]
, 2018 [ES] La esclerosis lateral amiotrófica (ELA), es un trastorno neurodegenerativo que afecta a las motoneuronas a nivel cerebral, troncal y espinal, causando debilidad y atrofia muscular progresiva y finalmente, la muerte.
Etxabe Gurrutxaga, Josune
core