Results 141 to 150 of about 756,924 (286)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Target-site resistance to pyrethroids in heliothis virescens (F.) and Helicoverpa zea (Boddie)
, 1998 A neurophysiological assay was used to record and compare target-site sensitivities to the pyrethroid insecticide, allethrin, in larvae and adults of the tobacco budworm, Heliothis virescens (F.) and larvae of the bollworm, Helicoverpa zea (Boddie). High
Ottea, J. A., Holloway, J. W.
core +1 more source
Evolution of the Pyrethroids Target-Site Resistance Mechanisms in Senegal: Early Stage of the <i>Vgsc-1014F</i> and <i>Vgsc-1014S</i> Allelic Frequencies Shift. [PDF]
Genes (Basel), 2021 Diallo M +11 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Investigation of the intrinsic mechanism of drug resistance in multiple myeloma [PDF]
, 2011 The focus of this thesis was to evaluate the mechanisms whereby myeloma cells develop intrinsic resistance with a focus on resistance in the context of bortezomib treatment.
Ooi, Melissa
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Gene amplification and insecticide resistance
, 2011 Pesticide resistance in arthropods has been shown to evolve by two main mechanisms, the enhanced production of metabolic enzymes, which bind to and/or detoxify the pesticide, and mutation of the target protein, which makes it less sensitive to the ...
Field, L. M. +3 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Target site modifications in the ribosome as antibiotic resistance mechanisms.
, 2008 Target site modifications in the ribosome as antibiotic resistance ...
Seok-Ming. Toh (7988285)
core
Non-target-site resistance to ALS inhibitors in waterhemp [PDF]
, 2014 The acetolactate synthase (ALS) enzyme, or acetohydroxyacid synthase (AHAS) enzyme, is an essential enzyme in branched-chain amino acid biosynthesis, and is the target site of five families of herbicides referred to as ALS inhibitors.
Guo, Jiaqi
core