Results 151 to 160 of about 8,010,330 (245)

Widespread non-target-site resistance in Setaria viridis to four classes of herbicide. [PDF]

Theor Appl Genet
Pendergast TH, Maddali S, Chaluvadi SR, Qi P, Vencill WK, Bennetzen JL, Devos KM.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Simultaneous detection of glyphosate and glufosinate target-site resistance in Eleusine indica via multiplex TaqMan qPCR. [PDF]

Pest Manag Sci
Lv YZ, Luo XY, Li XY, You JJ, Tian XS, Zhang C.   +5 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Engineering resilient gene drives for sustainable malaria control by predicting, testing and overcoming target site resistance in Anopheles gambiae. [PDF]

PLoS Biol
Morianou I, Phillimore L, Khatri BS, Marston L, Gribble M, Burt A, Bernardini F, Hammond AM, Nolan T, Crisanti A.   +9 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Susceptibility profile of Anopheles and target site resistance mechanism against organophosphates in Cameroon. [PDF]

PLoS One
Dandi-Labou J, Kengne-Ouafo JA, Mugenzi L, Tchouakui M, Wondji M, Wondji CS.   +5 more
europepmc   +1 more source

Occurrence of non-target-site-based resistance to ALS inhibitors in the broadleaf weed Papaver rhoeas (corn poppy).

, 2013
The vast majority of reported cases of resistance to ALS inhibitors in broadleaves is due to the selection of mutant, herbicide-resistant ALS alleles carrying a mutation at one of a few ALS codons that can be easily identified (ALS-based resistance). Non-
Délye C, Scarabel L
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Analysis of the resistance level and target site resistance mechanisms of Echinochloa crus-galli to penoxsulam from Hubei Province, China. [PDF]

PeerJ
Gu Q, Shen J, Chu S, Huang Q, Chen A, Li L, Li R.   +6 more
europepmc   +1 more source