Results 71 to 80 of about 1,389,981 (273)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

"Non-Target-Site" resistance mechanisms of "Papaver rhoeas" L. biotypes with multiple resistance [PDF]

, 2015
Hasta el momento en España no se han desarrollado estudios a fin de evaluar los mecanismos de resistencia “Non-Target-Site” en “Papaver rhoeas”. Tras constatar la resistencia múltiple de los biotipos empleados en este ensayo, los resultados de absorción ...
Menéndez, J., Rey Caballero, J., Salas, M., Torra, J.   +3 more
core  

L925I mutation in the Para-type sodium channel is associated with pyrethroid resistance in Triatoma infestans from the Gran Chaco region [PDF]

, 2014
Background: Chagas' disease is an important public health concern in Latin America. Despite intensive vector control efforts using pyrethroid insecticides, the elimination of Triatoma infestans has failed in the Gran Chaco, an ecoregion that extends over
Capriotti, Natalia, Mougabure Cueto, Gastón Adolfo, Ons, Sheila, Rivera Pomar, Rolando   +3 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Coexistence of target-site and non-target-site mechanisms of glyphosate resistance in Amaranthus palmeri populations from Argentina

Acta Scientiarum. Agronomy, 2021
Amaranthus palmeri S. Waston is currently one of the most problematic weeds worldwide. Biotypes with resistance to herbicides such as glyphosate and ALS inhibitors are now present in almost all Argentinian cultivable areas. In this work, we studied glyphosate resistance in three different populations, some of them previously characterized as resistant ...
Alvaro S. Larran, Valeria E Palmieri, Daniel Tuesca, Hugo R. Permingeat, Valeria Perotti   +4 more
openaire   +5 more sources

Proposal for a unified nomenclature for target site mutations associated with resistance to fungicides [PDF]

, 2016
Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein.
Brown, James KM, Burnett, Fiona, Clark, William, Cools, Hans, Fillinger, Sabine, Fraaije, Bart, Hollomon, Derek, Ishii, Hideo, Lopz-Ruiz, Francisco, Mair, Wesley, Mehl, Andreas, Mellado, Emilia, Oliver, Richard P., Schnabel, Guido, Shaw, Michael, Stammler, Gerd, Thind, Tarlochan S., Walker, Anne-Sophie   +17 more
core   +6 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Nucleotide Diversity at Site 106 of EPSPS in Lolium perenne L. ssp. multiflorum from California Indicates Multiple Evolutionary Origins of Herbicide Resistance

Frontiers in Plant Science, 2017
The repeated evolution of herbicide resistance in weeds is an ongoing problem in agricultural regions across the world, and presents a unique system in which to study the origins and spread of adaptive traits across heterogeneous landscapes.
Elizabeth Karn, Marie Jasieniuk
doaj   +1 more source

Role of a novel I1781T mutation and other mechanisms in conferring resistance to acetyl-CoA carboxylase inhibiting herbicides in a black-grass population. [PDF]

PLoS ONE, 2013
BACKGROUND: Knowledge of the mechanisms of herbicide resistance is important for designing long term sustainable weed management strategies. Here, we have used an integrated biology and molecular approach to investigate the mechanisms of resistance to ...
Shiv Shankhar Kaundun, Sarah-Jane Hutchings, Richard P Dale, Eddie McIndoe   +3 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source