Results 71 to 80 of about 1,387,158 (290)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Proposal for a unified nomenclature for target site mutations associated with resistance to fungicides [PDF]
, 2016 Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein.
Brown, James KM +17 more
core +6 more sources
Acta Scientiarum. Agronomy, 2021 Amaranthus palmeri S. Waston is currently one of the most problematic weeds worldwide. Biotypes with resistance to herbicides such as glyphosate and ALS inhibitors are now present in almost all Argentinian cultivable areas. In this work, we studied glyphosate resistance in three different populations, some of them previously characterized as resistant ...
Alvaro S. Larran +4 more
openaire +5 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Role of a novel I1781T mutation and other mechanisms in conferring resistance to acetyl-CoA carboxylase inhibiting herbicides in a black-grass population. [PDF]
PLoS ONE, 2013 BACKGROUND: Knowledge of the mechanisms of herbicide resistance is important for designing long term sustainable weed management strategies. Here, we have used an integrated biology and molecular approach to investigate the mechanisms of resistance to ...
Shiv Shankhar Kaundun +3 more
doaj +1 more source
"Non-Target-Site" resistance mechanisms of "Papaver rhoeas" L. biotypes with multiple resistance [PDF]
, 2015 Hasta el momento en España no se han desarrollado estudios a fin de evaluar los mecanismos de resistencia “Non-Target-Site” en “Papaver rhoeas”. Tras constatar la resistencia múltiple de los biotipos empleados en este ensayo, los resultados de absorción ...
Menéndez, J. +3 more
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Frontiers in Plant Science, 2017 The repeated evolution of herbicide resistance in weeds is an ongoing problem in agricultural regions across the world, and presents a unique system in which to study the origins and spread of adaptive traits across heterogeneous landscapes.
Elizabeth Karn, Marie Jasieniuk
doaj +1 more source
Reliability analysis of a glulam beam [PDF]
, 2007 The present case study is an example of the use of reliability analysis to asses the failure probability of a tapered glulam beam. This beam is part of a true structure built for a super market in the town of Kokemaki in Finland. The reliability analysis
Schnabl, Simon +2 more
core +2 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source