Results 111 to 120 of about 2,545,393 (299)
BMC Primary CareBackground Improving health equity and access to the highest possible standard of health care is a key issue of social accountability. Centretown Community Health Centre in Ottawa, Canada has iteratively developed a program to target and serve ...
Soha Khorsand +7 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Purchasing Strategies to Improve Care Management for Complex Populations: A National Scan of State Purchasers [PDF]
, 2008 Explores cost-effective alternatives to fee-for-service plans and full-risk managed care for Medicaid's aged, blind, and disabled or Supplementary Security Income beneficiaries.
Chad Shearer +3 more
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Economics of Science, 2017 The article considers socio-demographic issues of research and development of the «Federal Target Program for Research and Development in Priority Areas of Development of the Russian Scientific and Technological Complex for 2014–2020». Analysis based on project's documents in the Program from 2014 to 2016.
Chernova, I.N. +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
GraphX: Unifying Data-Parallel and Graph-Parallel Analytics [PDF]
, 2014 From social networks to language modeling, the growing scale and importance of graph data has driven the development of numerous new graph-parallel systems (e.g., Pregel, GraphLab). By restricting the computation that can be expressed and introducing new
Crankshaw, Daniel +5 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Путеводитель предпринимателя, 2020 The article deals with methods of valuation of goods, works and services in the implementation of procurement under the Federal Act on July 21, 2005 № 94-FZ "On Procurement of goods, works and services for state and municipal needs "in relation to R & D ...
doaj