Results 151 to 160 of about 2,545,393 (299)

A Computational Modeling for Reconfigurable Biosensors. [PDF]

Bionanoscience
Grasso R, Gonzalez-Medina JM, Barbruni GL, Carrara S.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Optimization of RNP-CRISPR for high-efficiency gene editing in mouse intestinal organoids. [PDF]

Mol Cell Biochem
Cao X, He Y, Guo H, Cao X, Zhang D, Lai Y, Yang W, Ma Z, Yu X, Wang L, Li D, Zeng Z.   +11 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

RPA Combined With CRISPR/Cas12a for Rapid and Ultrasensitive Detection Dual-Gene of Methicillin-Resistant Staphylococcus aureus (MRSA). [PDF]

J Mol Recognit
Chen L, Luo J, Zhang H, Zhao P.
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Closed-Form Approximations of Range Mutual Information for Integrated Sensing and Communication Systems. [PDF]

Sensors (Basel)
Lai Z, Luo H, Wang Y, Zhang Y, Jin B.
europepmc   +1 more source

Mechanisms of management of development of regional agro-industrial complexes on basis of program-target approach

Engineering for Rural Development, 2018
Vasilii Trenev, Tatiana Treneva
openaire   +1 more source

Results of the implementation of the program of targeted geological exploration works for the purpose of studying the Paleozoic complex of the Bukhara-Khiva region of the Republic of Uzbekistan [PDF]

Actual Problems of Oil and Gas, 2020
G.S. Abdullaev, N.K. Eidelnant, A.N. Bogdanov   +2 more
openaire   +1 more source