Results 51 to 60 of about 2,749,023 (281)

Target deconvolution of HDAC pharmacopoeia highlights MBLAC2 as common off-target

, 2021
Abstract HDAC drugs have entered the pharmacopoeia in the 2000s. However, some enigmatic phenotypes suggest off-target engagement. Here, we developed a chemical proteomics assay using three promiscuous chemotypes and quantitative mass spectrometry that we deployed to establish the target landscape of 53 drugs.
Severin Lechner, Martin Malgapo, Christian Grätz, Agnes Baron, Patrick Leopold Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Wolfgang Sippl, Mathias Wilhelm, Karin Kleigrewe, Josch Pauling, Karl Kramer, Michael Pfaffl, Maurine Linder, Bernhard Kuster, Guillaume Médard   +22 more
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Ma-Weber/Tutorial-Deconvolution: Update to correct spelling errors

, 2020
This tutorial presents and explains examples of the deconvolution of hydrophone measurement data. The motivation for performing deconvolution is that, in many cases, measurements of ultrasonic signals are performed with a hydrophone that is (more or less)
Martin Weber, Sascha Eichstädt, Volker Wilkens   +2 more
core   +1 more source

New Advances in Cell Microarray Technology to Expand Applications in Target Deconvolution and Off-Target Screening [PDF]

SLAS Discovery, 2020
Identifying the cell surface receptors of natural ligands, and deconvoluting the receptor targets of candidate drug leads, presents a challenge in medical research and drug discovery. Traditionally, success rates have been low, and screening efforts often generate numerous false-positive hits that require extensive follow-up to either validate or ...
Jim, Freeth, Jo, Soden
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Determination of EPID convolution kernels for portal imaging using carbon target bremsstrahlung

Current Directions in Biomedical Engineering, 2017
Improving the accuracy and reproducibility during patient positioning is of paramount importance. Hence, the goal of this work is to characterize the aspects of image blurring occurring during carbon target bremsstrahlung portal imaging and to assess the
Lüdeke Sascha, Wyrwoll Vanessa, Stelljes Tenzin S., Looe Hui Khee, Harder Dietrich, Poppe Björn   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Uncovering the Mechanism of Action of Antiprotozoal Agents: A Survey on Photoaffinity Labeling Strategy

Pharmaceuticals
Plasmodium, Leishmania, and Trypanosoma parasites are responsible for infectious diseases threatening millions of people worldwide. Despite more recent efforts devoted to the search for new antiprotozoal agents, efficacy, safety, and resistance issues ...
Alessandro Giraudo, Cristiano Bolchi, Marco Pallavicini, Roberto Di Santo, Roberta Costi, Francesco Saccoliti   +5 more
doaj   +1 more source

Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer

Computational and Structural Biotechnology Journal, 2020
While high-throughput drug screening offers possibilities to profile phenotypic responses of hundreds of compounds, elucidation of the cell context-specific mechanisms of drug action requires additional analyses. To that end, we developed a computational
Tianduanyi Wang, Prson Gautam, Juho Rousu, Tero Aittokallio   +3 more
doaj   +1 more source

An Image Quality Improvement Method in Side-Scan Sonar Based on Deconvolution

Remote Sensing, 2023
Side-scan sonar (SSS) is an important underwater imaging method that has high resolutions and is convenient to use. However, due to the restriction of conventional pulse compression technology, the side-scan sonar beam sidelobe in the range direction is ...
Jia Liu, Yan Pang, Lengleng Yan, Hanhao Zhu   +3 more
doaj   +1 more source