Results 181 to 190 of about 6,355,269 (225)
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Comptes Rendus de l'Académie des Sciences - Series IV - Physics, 2000
Abstract We recall the main features of the LMJ. By using a simple but global model we determined different shells able to give a thermonuclear yield larger than 15 MJ; this model delimited an operating domain for the laser with a 25% margin to take into account the poorly understood phenomena.
Pierre-André Holstein +20 more
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Abstract We recall the main features of the LMJ. By using a simple but global model we determined different shells able to give a thermonuclear yield larger than 15 MJ; this model delimited an operating domain for the laser with a 25% margin to take into account the poorly understood phenomena.
Pierre-André Holstein +20 more
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Auction Design with a Revenue Target
2015In many fund-raising situations, a revenue target is specified. This suggests that the fund-raiser is interested in maximizing the probability to achieve this revenue target, rather than in maximizing the expected revenue. We study this topic from the perspective of Bayesian mechanism design, in a setting where a seller has a certain good that he can ...
Paul W. Goldberg, Bo Tang
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Trial Designs for Targeted Therapies
Biometrical Journal, 2006AbstractThis is a discussion of the paper ‘Making efficient use of patients in designing phase III trials investigating simultaneously a set of targeted therapies with different targets’ by Werner Vach and Rene dePont Christensen. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
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Design of Target-Seeking Antifibrotic Compounds
2012Selective delivery of drugs and biotherapeutics to the site of disease (synaphic targeting) has a number of advantages. First, the enhanced accumulation of the therapeutic compound at the target tissue increases drug efficacy without increasing side effects. Alternatively, the dose of the drug can be lowered to reduce the side effects. On the practical
Järvinen Tero, Järvinen Tero
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Targeted Covalent Inhibitors for Drug Design
Angewandte Chemie International Edition, 2016AbstractIn contrast to the traditional mechanism of drug action that relies on the reversible, noncovalent interaction of a ligand with its biological target, a targeted covalent inhibitor (TCI) is designed such that the initial, reversible association is followed by the formation of a covalent bond between an electrophile on the ligand and a ...
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Incorporating target heterogeneity in drug design
Journal of Cellular Biochemistry, 2001Traditionally, structure-based drug design has been predicated on the idea of the lock-and-key hypothesis, i.e., the ideal drug should have a structure that complements the target site structurally and energetically. The implementation of this idea has lead to the development of drug molecules that are conformationally constrained and pre-shaped to the
A, Velazquez-Campoy, E, Freire
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Asynchronous logic design targeting LUTs
2018 7th Mediterranean Conference on Embedded Computing (MECO), 2018The conventional approach to logic design targeting LUTs of limited inputs number is oriented on multi-level decomposition. Nowadays reconfigurable chips contain multiple LUTs that can be combined. It implies producing LUT-based structure of various inputs number to match design needs.
Igor Lemberski, Artjoms Suponenkovs
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Infrared target design: fabrication considerations
Applied Optics, 1981The fabrication issues involved in the design of an infrared target are presented.
M S, Scholl, W L, Wolfe
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Design and Fabrication of 3D Fingerprint Targets
IEEE Transactions on Information Forensics and Security, 2016Standard targets are typically used for structural (white-box) evaluation of fingerprint readers, e.g., for calibrating imaging components of a reader. However, there is no standard method for behavioral (black-box) evaluation of fingerprint readers in operational settings where variations in finger placement by the user are encountered.
Sunpreet S. Arora +3 more
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Viral Proteases as Targets for Drug Design
Current Pharmaceutical Design, 2012In order to productively infect a host, viruses must enter the cell and force host cell replication mechanisms to produce new infectious virus particles. The success of this process unfortunately results in disease progression and, in the case of infection with many viral species, may cause mortality.
Marcin, Skoreński, Marcin, Sieńczyk
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