Results 31 to 40 of about 6,355,269 (225)
2022 FDA TIDES (Peptides and Oligonucleotides) Harvest
Pharmaceuticals, 2023 A total of 37 new drug entities were approved in 2022; although that year registered the lowest number of drug approvals since 2016, the TIDES class consolidated its presence with a total of five authorizations (four peptides and one oligonucleotide ...
Othman Al Musaimi +3 more
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Journal of Physics: Conference Series, 2023 Abstract The Muon station for sciEnce, technoLOgy and inDustrY (MELODY) is foreseen to be the first muon source in China and to be located at the China Spallation Neutron Source in Dongguan. The stand-alone target station has been studied for the surface muons and the pions production. In this report, we aim to describe the design of the
Lei Liu +6 more
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Design of On-Target FAAH Inhibitors [PDF]
Chemistry & Biology, 2005 In this issue of Chemistry & Biology, Alexander and Cravatt propose a model for the binding of carbamate inhibitors to fatty acid amide hydrolase (FAAH), the enzyme that breaks down signaling lipids. Using competitive activity-based protein profiling and click chemistry, they designed potent and selective FAAH inhibitors and characterized their off ...
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IPDA filters in the sense of Gaussian mixture PHD algorithm [PDF]
Scientific Technical Review, 2016 The Integrated Probabilistic Data Association (IPDA) type filters provide estimates of the underlying target probability of existence as well as they track state maintenance. For each scan, IPDA recursive calculates the probability of target existence in
Radosavljević Zvonko
doaj
Path planning for moving target tracking by fixed-wing UAV
Defence Technology, 2020 For the automatic tracking of unknown moving targets on the ground, most of the commonly used methods involve circling above the target. With such a tracking mode, there is a moving laser spot on the target, which will bring trouble for cooperative ...
Song-lin Liao +5 more
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Interspeech, 2017 International audienceDesignation consists in attracting an interlocutor's attention on a specific object and/or location. It is most often achieved using both speech (e.g., demonstratives) and gestures (e.g., manual pointing).
Marion Dohen, B. Roustan
semanticscholar +2 more sources
SIAM/ASA Journal on Uncertainty QuantificationSIAM/ASA Journal on Uncertainty Quantification, Accepted ...
Carlo Graziani, Marieme Ngom
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Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration [PDF]
Frontiers in Neuroscience, 2016 HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A ...
Ramsay Rona, R. +3 more
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Molecular Therapy: Methods & Clinical Development, 2019 Advanced therapy medicinal products (ATMPs) require evaluation by the European Medicines Agency’s Committee for Advanced Therapies prior to being placed on the European market, subject to a Marketing Authorisation granted by the European Commission.
Giulia Detela, Anthony Lodge
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Targeting targeted agents: open issues for clinical trial design [PDF]
Journal of Experimental & Clinical Cancer Research, 2009 Molecularly targeted agents for the treatment of solid tumors had entered the market in the last 5 years, with a great impact upon both the scientific community and the society. Many randomized phase III trials conducted in recent years with new targeted agents, despite previous data coming from preclinical research and from phase II trials were often ...
Emilio Bria +6 more
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