Results 211 to 220 of about 104,887 (271)

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. [PDF]

Genetics
Hu Y, Rodiger J, Liu Y, Gao C, Liu Y, Qadiri M, Veal A, Bulyk ML, Perrimon N.   +8 more
europepmc   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Evaluation of triphenyl phosphate's pathogenic potential and molecular mechanisms in glioblastoma: an integrated network toxicology investigation employing multiple machine learning approaches. [PDF]

Transl Cancer Res
Wang Z, Cui K, Wang J, Ma R, Wang Y.
europepmc   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Constructing the spatiotemporal atlas of single-cell lineage trajectories in stereotypic biological structures. [PDF]

iScience
Wang R, Yang X, Lian C, Wang J, Chen J, Qian Y, Xu Y, Wang L, Marioni JC, Tam PPL, Jing N.   +10 more
europepmc   +1 more source

Countering the parking lot attack: employing monopulse radar methods to detect and geo-locate RF targets operating in the 2.4 GHz ISM band

, 2018
openaire   +2 more sources

Verification and Mitigation of Proton‐Induced Non‐Ionizing Damage in Perovskite Solar Cells for Space Applications

Advanced Energy Materials, EarlyView.
Metal‐halide perovskite solar cells offer high‐efficiency power for orbital missions but suffer from permanent proton‐induced degradation. This work identifies non‐ionizing energy loss (NIEL) as the primary driver of irreversible failure, inducing atomic displacements and microcracks in the high‐fluence regime. Through energy‐tuned mapping and scalable
Jangwon Byun, Sung‐Pil Yoon, Beomjun Park, Sung‐Jun Park, Dong Hoe Kim, Sunwoo Kim, Jin‐Wook Lee, Sangwook Lee, Hyun Suk Jung, Nam‐Gyu Park, Man‐Jong Lee   +10 more
wiley   +1 more source

DARS2 serves as an independent prognostic factor and participates in multiple biological processes in bladder urothelial carcinoma. [PDF]

Transl Androl Urol
Qiu R, Lin T, Dong L, He M, Deng S, Xu S, Deng Z, Deng C, Guo C.   +8 more
europepmc   +1 more source