Results 231 to 240 of about 104,887 (271)

Uncovering the Key Circuit FOSL2/FOS/EGR3/EGR1, Contributing to the Hyperexcitability of Excitatory Neurons in the Epileptic Temporal Cortex and Hippocampus. [PDF]

Int J Mol Sci
Chen J, Zhao B, Yang K, Mi W, Huang X, Jiang W, Hu C, Wang Z, Zhang Y, Li X.   +9 more
europepmc   +1 more source

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

Annals of Neurology, EarlyView.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto, Michael Bonomo, Brianna S. Nelthrope, Benjamin D. Carr, Emma Palmer, Mariana Sierra, Ilkim Erturk, David Peppercorn, Eleonor Cox, Tiare K. Vasconcellos, Henry L. Paulson, Hannah K. Shorrock, Sharan R. Srinivasan   +12 more
wiley   +1 more source

<i>GPR176</i> represses mitophagy to promote the progression of osteosarcoma by facilitating mTORC1 activity via PI3K-AKT pathway. [PDF]

Transl Cancer Res
Jiang J, Zheng B, Wang J, Fang Y, Yang L, Lv J, Liang H.   +6 more
europepmc   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, EarlyView.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Identification of GPD1L as a potential prognosis biomarker and associated with colorectal cancer progression. [PDF]

Discov Oncol
Liu YR, Zeng Y, Mei C, Xu YH, Zhang HB, Liang R, Wang G.   +6 more
europepmc   +1 more source

M2 macrophage-associated factors for constructing a prognostic model for osteosarcoma. [PDF]

Medicine (Baltimore)
Han J.
europepmc   +1 more source

STTORM-CD low-demand and high-impact disaster monitoring onboard satellites using change detection. [PDF]

Sci Rep
Herec J, Sedmidubsky J, Pitoňák R.
europepmc   +1 more source

Implicit 3D geological modeling method based on expert knowledge constraints: A case study from the Songshugang Mining District, Hengfeng County, Jiangxi Province, China. [PDF]

PLoS One
Jin W, Wu Z, Xu Z, Li H, Li B, Guo F, Zhang Z, Ma F, Li H, Lu P.   +9 more
europepmc   +1 more source

FSCN1 drives sarcoma progression and immunosuppression revealed by pan-cancer analysis and functional assays. [PDF]

Discov Oncol
Xu L, Jin S, Dong X, Zhao X, Xu T, Guo Y, Tao L, Pang L.   +7 more
europepmc   +1 more source

Geometric multi-instance learning for weakly supervised gastric cancer segmentation. [PDF]

NPJ Digit Med
Huang C, Xia H, Xiao X, Chen H, Jiang Y, Lyu Y, Ni Z, Wang T, Wang N, Huang Q.   +9 more
europepmc   +1 more source