Results 61 to 70 of about 104,887 (271)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Target Area Georeference Algorithm for Evaluating the Impact of High-Speed Weapon

International Journal of Technology
Evaluation of air-to-ground shooting exercises using Weapon Scoring System (WSS) is very important for the military to achieve Network Centric Warfare (NCW).
Ardian Infantono, Ridi Ferdiana, Rudy Hartanto   +2 more
doaj   +1 more source

Extreme deep learning in biosecurity: the case of machine hearing for marine species identification

Journal of Information and Telecommunication, 2018
Biosafety is defined as a set of preventive measures aimed at reducing the risk of infectious diseases’ spread to crops and animals, by providing quarantine pesticides.
Konstantinos Demertzis, Lazaros S. Iliadis, Vardis-Dimitris Anezakis   +2 more
doaj   +1 more source

Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin

Molecular Cancer, 2021
Background Cis-diamminedichloro-platinum (CDDP)-based chemotherapy regimens are the most predominant treatment strategies for patients with esophageal squamous cell carcinoma (ESCC).
Yunlong Jia, Cong Tian, Hongyan Wang, Fan Yu, Wei Lv, Yuqing Duan, Zishuo Cheng, Xuexiao Wang, Yu Wang, Tianxu Liu, Jiali Wang, Lihua Liu   +11 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Representation, focus, and movement of covert visual attention [PDF]

, 2004
This thesis investigated some of the factors involved in the representation, focus, and movement of covert attention in visual space. Existing research has shown that visual cues produced a facilitation of reaction times (RTs) to visual targets appearing
Hola, Alicja Krystyna Wanda
core  

Attentional preparation for a lateralized visual distractor: Behavioral and fMRI evidence

, 2006
Attending to the location of all expected visual target call lead to anticipatory activations In spatiotopic occipital cortex, emerging before target onset.
Christian C. Ruff, Ruff, CC, Jon Driver, Driver, J   +3 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Competitive Facility Location with Competition of Customers

, 2015
The research work dealing with the competitive location problems is limited only to the competition among the locators, that is, it is supposed that either both the locator and the allocator are the same or the customer knows the optimality criterion of ...
Athanasia Karakitsiou, Karakitsiou, Athanasia,   +1 more
core   +1 more source

Do Statistical Learning of Target Location and Distractor Location Rely on Same Mechanisms During Visual Search

, 2022
Despite rich empirical findings, it is not clear how the two forms of SL (SL of target location and SL of distractor location) influence visual search and whether they share the same cognitive mechanism.
Xing Zhou
core   +1 more source