Results 71 to 80 of about 104,887 (271)
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Performance Analysis of Satellite Missions for Multi-Temporal SAR Interferometry
Sensors, 2018 Multi-temporal InSAR (MTI) applications pose challenges related to the availability of coherent scattering from the ground surface, the complexity of the ground deformations, atmospheric artifacts, and visibility problems related to ground elevation ...
Fabio Bovenga +6 more
doaj +1 more source
Location matters: Why target location impacts performance in orientation tasks
, 2018 This research explores human performance in a spatial orientation task. In three experiments, participants saw a target highlighted in a visual scene and were asked to locate it on a map of the space.
John R. Anderson (294859) +1 more
core +1 more source
Survival analysis results for the 52 core target genes (performed in 214 CRC samples from GEO).
, 2022 Survival analysis results for the 52 core target genes (performed in 214 CRC samples from GEO).
Jiaxin Du (125802) +14 more
core +1 more source
Advanced Science, EarlyView.In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin +13 more
wiley +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Extensions to emergency vehicle location models [PDF]
, 2003 This paper is concerned with extending models for the Maximal Covering Location Problem in two ways. First, the usual 0-1 coverage definition is replaced by the probability of covering a demand within the target time.
Rand, G K, Alsalloum, O I
core
, 2013 The grasping and stabilization of a spinning, noncooperative target satellite by means of a free-flying robot is addressed. A method for computing feasible robot trajectories for grasping a target with known geometry in a useful time is presented ...
Hirzinger, Gerd +3 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
Frontiers in GeneticsObjectiveThe study assessed the expression of STC1, and its potential as an immunotherapy target in gastric cancer (GC).MethodsRNAseq data from the TCGA_STAD project and TCGA-GTEx project of UCSC XENA website and microarray data from GEO (GSE66229) were ...
Weijun Ma, Xiaoli Ma, Yaoqi Li
doaj +1 more source