Results 91 to 100 of about 6,846,778 (296)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Mask-Predict: Parallel Decoding of Conditional Masked Language Models
, 2019 Most machine translation systems generate text autoregressively from left to right. We, instead, use a masked language modeling objective to train a model to predict any subset of the target words, conditioned on both the input text and a partially ...
Ghazvininejad, Marjan +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Target-specific glioma therapy in an immunocompetent mouse model : meeting abstract [PDF]
, 2006 Objective: Establishment of an immunocompetent mouse model representing the typical progressive stages observed in malignant human gliomas for the in vivo evaluation of novel target-specific regimens.
Baus, Daniela +7 more
core
Target Set in Threshold Models
, 2019 Consider a graph $G$ and an initial coloring, where each node is blue or red. In each round, all nodes simultaneously update their color based on a predefined rule. In a threshold model, a node becomes blue if a certain number or fraction of its neighbors are blue and red otherwise.
openaire +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
SensorsIn complex environments, traditional multi-target tracking methods often encounter challenges such as strong clutter interference and interruptions in target trajectories, which can result in insufficient tracking accuracy and robustness.
Ziqian Yang +3 more
doaj +1 more source
Target Saving In An Overlapping Generations Model [PDF]
We examine a model in which the utility function has been engineered so that it is optimal for consumers to aim for a fixed target level of retirement resources.
Ashok S. Guha, Brishti Guha
core
Admissible target paths in economic models [PDF]
Journal of Economic Dynamics and Control, 1993 Abstract In this paper we answer the question which dynamic target paths can be achieved in an economy described by a linear time-varying difference equation. Additionally, we discuss the advantages and disadvantages of various policies that yield tracking of those paths.
openaire +7 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source