Results 111 to 120 of about 6,846,778 (296)
Comparative Modeling of Drug Target Proteins☆
, 2014 In this perspective, we begin by describing the comparative protein structure modeling technique and the accuracy of the corresponding models. We then discuss the significant role that comparative prediction plays in drug discovery. We focus on virtual ligand screening against comparative models and illustrate the state-of-the-art by a number of ...
Webb, B. +6 more
openaire +1 more source
Interval models for target tracking algorithms
Mathematical and Computer Modelling, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Cong, Shan, Hong, Lang
openaire +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
DCGAN Feature-Enhancement-Based YOLOv8n Model in Small-Sample Target Detection
ComputersThis paper proposes DCGAN-YOLOv8n, an integrated framework that significantly advances small-sample target detection by synergizing generative adversarial feature enhancement with multi-scale representation learning. The model’s core contribution lies in
Peng Zheng +7 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome
Signal Transduction and Targeted Therapy, 2021 Weiqi Hong +10 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Learning Unsupervised Cross-Domain Model for TIR Target Tracking
MathematicsThe limited availability of thermal infrared (TIR) training samples leads to suboptimal target representation by convolutional feature extraction networks, which adversely impacts the accuracy of TIR target tracking methods.
Xiu Shu +4 more
doaj +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source