Results 71 to 80 of about 6,846,778 (296)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Large-Scale Domain Adaptation via Teacher-Student Learning

, 2017
High accuracy speech recognition requires a large amount of transcribed data for supervised training. In the absence of such data, domain adaptation of a well-trained acoustic model can be performed, but even here, high accuracy usually requires ...
Gong, Yifan, Li, Jinyu, Seltzer, Michael L., Wang, Xi, Zhao, Rui   +4 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Attention Focusing for Neural Machine Translation by Bridging Source and Target Embeddings

, 2018
In neural machine translation, a source sequence of words is encoded into a vector from which a target sequence is generated in the decoding phase. Differently from statistical machine translation, the associations between source words and their possible
Branco, António, Kuang, Shaohui, Li, Junhui, Luo, Weihua, Xiong, Deyi   +4 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Modeling Natural Killer Cell Targeted Immunotherapies [PDF]

Frontiers in Immunology, 2017
Animal models have extensively contributed to our understanding of human immunobiology and to uncover the underlying pathological mechanisms occurring in the development of diseases. However, mouse models do not reproduce the genetic and molecular complexity inherent in human disease conditions.
Lopez-Lastra, Silvia, Di Santo, James P.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Uncovering the key mechanisms of how deep decarbonization benefits air pollution alleviation in China

Environmental Research Letters, 2022
Addressing climate change and air pollution goals in conjunction would be efficient and cost-effective. Dealing with these two challenges is a common issue for urban clusters pursuing sustainable development.
Xiaorui Liu, Chaoyi Guo, Xiaotian Ma, Kai Wu, Peng Wang, Zhijiong Huang, Ziqiao Zhou, Chen Huang, Silu Zhang, Minghao Wang, Hancheng Dai   +10 more
doaj   +1 more source

Model-based target sonification on mobile devices [PDF]

, 2004
We investigate the use of audio and haptic feedback to augment the display of a mobile device controlled by tilt input. We provide an example of this based on Doppler effects, which highlight the user's approach to a target, or a target's movement from ...
Crossan, A., Eslambolchilar, P., Murray-Smith, R.   +2 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source