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Mitochondrial dynamics in vascular remodeling and target-organ damage [PDF]

Frontiers in Cardiovascular Medicine, 2023
Vascular remodeling is the pathological basis for the development of many cardiovascular diseases. The mechanisms underlying endothelial cell dysfunction, smooth muscle cell phenotypic switching, fibroblast activation, and inflammatory macrophage ...
Tong Zhu, Qingxun Hu, Qingxun Hu, Yanggang Yuan, Huijuan Yao, Jian Zhang, Jia Qi   +6 more
doaj   +3 more sources

Cerebro-Cardiovascular Risk, Target Organ Damage, and Treatment Outcomes in Primary Aldosteronism

Frontiers in Cardiovascular Medicine, 2022
Primary aldosteronism (PA) is the most common type of endocrine hypertension, and numerous experimental and clinical evidence have verified that prolonged exposure to excess aldosterone is responsible for an increased risk of cerebro-cardiovascular ...
Xiao Lin, Muhammad Hasnain Ehsan Ullah, Xiong Wu, Feng Xu, Su-Kang Shan, Li-Min Lei, Ling-Qing Yuan, Jun Liu, Jun Liu, Jun Liu   +9 more
doaj   +4 more sources

Interrelations Between Arterial Stiffness, Target Organ Damage, and Cardiovascular Disease Outcomes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Excess transmission of pressure pulsatility caused by increased arterial stiffness may incur microcirculatory damage in end organs (target organ damage [TOD]) and, in turn, elevate risk for cardiovascular disease (CVD) events.
Ramachandran S. Vasan, Meghan I. Short, Teemu J. Niiranen, Vanessa Xanthakis, Charles DeCarli, Susan Cheng, Sudha Seshadri, Gary F. Mitchell   +7 more
doaj   +4 more sources

Cardiac and Vascular Target Organ Damage in Pediatric Hypertension

Frontiers in Pediatrics, 2018
Atherosclerosis begins in youth and is associated with the presence of numerous modifiable cardiovascular (CV) risk factors, including hypertension. Pediatric hypertension has increased in prevalence since the 1980s but has plateaued in recent years ...
Michael Khoury, Elaine M. Urbina
doaj   +4 more sources

Natural compounds targeting mitochondrial dysfunction: emerging therapeutics for target organ damage in hypertension

Frontiers in Pharmacology, 2023
Hypertension generally causes target organ damage (TOD) in the heart, brain, kidney, and blood vessels. This can result in atherosclerosis, plaque formation, cardiovascular and cerebrovascular events, and renal failure. Recent studies have indicated that
Xiaolin Liao, Yuanshan Han, Ying He, Jianjun Liu, Yuhong Wang   +4 more
doaj   +2 more sources

Temporal patterns of pre- and post-natal target organ damage associated with hypertensive pregnancy: a systematic review. [PDF]

Eur J Prev Cardiol, 2023
Aims Hypertensive pregnancy is associated with increased risks of developing a range of vascular disorders in later life. Understanding when hypertensive target organ damage first emerges could guide optimal timing of preventive interventions.
Cutler HR, Barr L, Sattwika PD, Frost A, Alkhodari M, Kitt J, Lapidaire W, Lewandowski AJ, Leeson P.   +8 more
europepmc   +2 more sources

Target organ damage in newly detected hypertensive patients

Journal of Family Medicine and Primary Care, 2019
Background: Hypertension (HTN) is difficult to diagnose since it is asymptomatic. Most of the patients with HTN are unaware of their disease, and hence a large number of these subjects have target organ damage (TOD) on their first arrival at hospital or ...
Divya Prakash
doaj   +2 more sources

The cumulative blood pressure load and target organ damage in patients with essential hypertension

Journal of Clinical Hypertension, 2020
The area under the blood pressure curve is associated with target organ damage, but accurately estimating its value is challenging. This study aimed to improve the utility of the area under the blood pressure curve to predict hypertensive target organ ...
Zhou Bingqing
exaly   +2 more sources

Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans

BMC Medical Genomics, 2019
Background Epigenetic age acceleration, a measure of biological aging based on DNA methylation, is associated with cardiovascular mortality. However, little is known about its relationship with hypertensive target organ damage to the heart, kidneys ...
Jennifer A. Smith, Jeremy Raisky, Scott M. Ratliff, Jiaxuan Liu, Sharon L. R. Kardia, Stephen T. Turner, Thomas H. Mosley, Wei Zhao   +7 more
doaj   +2 more sources

Hypertension in Children: Narrative Review of Epidemiology, Outcome and Target Organ Damage [PDF]

Children
Hypertension is the leading risk factor for cardiovascular disease. Epidemiologic studies have demonstrated that pediatric hypertension may increase the risk of premature heart disease.
Joseph Mahgerefteh
doaj   +2 more sources