Results 71 to 80 of about 8,510,768 (280)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling

, 2008
Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes.
Field, L.M., Andrias O O'Reilly, Williamson, M.S., Wallace, Bonnie A., BA Wallace, Linda M Field, TG Emyr Davies, Wallace, B. A., Davies, T.G.E., O’Reilly, Andrias O., Field, L. M., O'Reilly, A. O., Davies, T. G. E., Martin S Williamson, Williamson, M. S., Davies, Emyr, Field, Lin, Williamson, Martin   +17 more
core   +1 more source

Long-term trends in Anopheles gambiae insecticide resistance in Côte d'Ivoire [PDF]

, 2014
Malaria control is heavily dependent on the use of insecticides that target adult mosquito vectors via insecticide treated nets (ITNs) or indoor residual spraying (IRS).
Barry, Sarah, Bassirou Bonfoh, Barry, Sarah J.E., N'goran, Eliezer K., Chouaibou, Mouhamadou, Johnson, Paul, Eliezer K N’Goran, Louise Bellai, Adja, Akre M., Benjamin G Koudou, Akre M Adja, Dongus, Stefan, Ranson, Hilary, Edi, Constant A.V., N’Goran, Eliezer K., Weetman, David; id_orcid, Koudou, Benjamin G., Johnson, Paul C.D., Bonfoh, Bassirou, Pie Müller, Ranson, Hilary; id_orcid, Sarah JE Barry, Constant AV Edi, Edi, Constant, Müller, Pie, Paul CD Johnson, Stefan Dongus, David Weetman, Weetman, David, N. Goran, Eliezer K., Bellai, Louise, Mouhamadou Chouaibou, Hilary Ranson, Ranson H, Chouaibou M, Weetman D, Bellai L, Bonfoh B, Adja AM, Dongus S, N'Goran EK, Koudou BG, Edi CA, Müller P, Barry SJ, Johnson PC   +45 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ile-1781-Leu Target Mutation and Non-Target-Site Mechanism Confer Resistance to Acetyl-CoA Carboxylase-Inhibiting Herbicides in Digitaria ciliaris var. chrysoblephara

, 2023
Digitaria ciliaris var. chrysoblephara is a xerophytic weed severely invading rice fields along with the application of rice mechanical direct seeding technology in China.
Qian Yang (300330), Jinlei Zhu (15494526), Xia Yang (46748), Min Lv (608418), Tian Wei (5533379), Yongfeng Li (135567)   +5 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance [PDF]

Scientific Reports, 2015
AbstractEmergence of genetic resistance against kinase inhibitors poses a great challenge for durable therapeutic response. Here, we report a novel mechanism of JAK2 kinase inhibition by fedratinib (TG101348) that prevents emergence of genetic resistance. Using in vitro drug screening, we identified 211 amino-acid substitutions conferring resistance to
Meenu Kesarwani, Erika Huber, Zachary Kincaid, Chris R. Evelyn, Jacek Biesiada, Mark Rance, Mahendra B. Thapa, Neil P. Shah, Jarek Meller, Yi Zheng, Mohammad Azam   +10 more
openaire   +2 more sources

Investigation and characterisation of diamide insecticide resistance conferred by target-site mutations in the Ryanodine Receptor of lepidopteran pests [PDF]

, 2019
Lepidopteran crop pests such as Tuta absoluta, Chilo suppressalis, Spodoptera frugiperda and Plutella xylostella are becoming increasingly problematic, as populations colonise new regions of the globe.
Richardson, E.
core  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Insecticide resistance resulting from an absence of target-site gene product [PDF]

Proceedings of the National Academy of Sciences, 1998
Genetic changes in insects that lead to insecticide resistance include point mutations and up-regulation/amplification of detoxification genes. Here, we report a third mechanism, resistance caused by an absence of gene product. Mutations of the Methoprene-tolerant ( Met
T G, Wilson, M, Ashok
openaire   +2 more sources