Results 291 to 300 of about 1,394,726 (329)
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Overcoming drug resistance: targeting more than one site
Leukemia Research, 2002Activation of the molecular machinery of programmed cell death (apoptosis) is a convergence point for many cytotoxic agents, irrespective of the primary mechanism of action. Indeed, apoptosis is induced in response to DNA strand breaks caused by such mechanistically diverse anti-leukemic drugs as the nucleoside cytosine arabinoside (ara-C ...
Judith E, Karp, Bijoyesh P, Mookerjee
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Pesticide Biochemistry and Physiology, 2019
Myosoton aquaticum L., a widespread and competitive winter weed of wheat in China, has evolved resistance to many classes of herbicides. In one M. aquaticum population (AH03), collected from Anhui Province, where tribenuron-methyl and florasulam had been used to control this weed resistance to both herbicides had evolved.
Shuang, Bai +7 more
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Myosoton aquaticum L., a widespread and competitive winter weed of wheat in China, has evolved resistance to many classes of herbicides. In one M. aquaticum population (AH03), collected from Anhui Province, where tribenuron-methyl and florasulam had been used to control this weed resistance to both herbicides had evolved.
Shuang, Bai +7 more
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Weed Science, 2022
AbstractThe full spectrum of herbicide resistance in a weed can vary according to the mechanistic basis and cannot be implied from the selective pressure. Common ragweed (Ambrosia artemisiifolia L.) is an important weed species of horticultural crops that has developed resistance to linuron based on either target site– or non–target site resistance ...
Martin Laforest +5 more
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AbstractThe full spectrum of herbicide resistance in a weed can vary according to the mechanistic basis and cannot be implied from the selective pressure. Common ragweed (Ambrosia artemisiifolia L.) is an important weed species of horticultural crops that has developed resistance to linuron based on either target site– or non–target site resistance ...
Martin Laforest +5 more
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R-factor trimethoprim resistance mechanism: An insusceptible target site
Biochemical and Biophysical Research Communications, 1974Abstract R-factor R388 increases the resistance of Escherichia coli to trimethoprim by 10,000 fold, and mediates the synthesis of an addional dihydrofolate reductase that is less susceptible to trimethoprim by a similar order of magnitude. The dihydrofolate reductase conferred by the R-factor was of a larger molecular weight than the wild-type ...
S G, Amyes, J T, Smith
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Plant Physiology and Biochemistry
Shortawn foxtail (Alopecurus aequalis Sobol.) is a noxious weed in China. The resistance of A. aequalis developed rapidly due to the long-term application of acetolactate synthase (ALS)-inhibiting herbicides. Here, a suspected mesosulfuron-methyl-resistant A.
You Zhan +5 more
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Shortawn foxtail (Alopecurus aequalis Sobol.) is a noxious weed in China. The resistance of A. aequalis developed rapidly due to the long-term application of acetolactate synthase (ALS)-inhibiting herbicides. Here, a suspected mesosulfuron-methyl-resistant A.
You Zhan +5 more
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Novel target sites in bacteria for overcoming antibiotic resistance
Advanced Drug Delivery Reviews, 2005Resistance to marketed antibiotics continues to increase. During the last 10 years some 200 bacterial genome sequences have become available, giving rise to expectations that genomics would provide a plethora of novel targets and hence a flood of new therapeutic agents.
Michael T, Black, John, Hodgson
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Bacterial resistance to antibiotics: Modified target sites
Advanced Drug Delivery Reviews, 2005Alteration in the target sites of antibiotics is a common mechanism of resistance. Examples of clinical strains showing resistance can be found for every class of antibiotic, regardless of the mechanism of action. Target site changes often result from spontaneous mutation of a bacterial gene on the chromosome and selection in the presence of the ...
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Mapping cryptic binding sites of drug targets to overcome drug resistance
Drug Resistance Updates, 2023The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their inhibitors can overcome drug resistance.
Yang-Yang, Gao +3 more
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Non-target Site Mechanisms of Resistance to Herbicides
Critical Reviews in Plant Sciences, 2017ABSTRACTEvolution of resistance in weeds to herbicides is threatening world agricultural production. Weed management has become more complicated with the development of non-target site resistance (NTSR) to herbicides in weeds. The NTSR mechanisms can be caused by herbicide metabolism, altered patterns of translocation, and herbicide absorption ...
Hossein Ghanizadeh, Kerry C. Harrington
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Target‐site mutation accumulation among ALS inhibitor‐resistant Palmer amaranth
Pest Management Science, 2018AbstractBACKGROUNDPalmer amaranth (Amaranthus palmeri S. Wats) is one of the most common and troublesome weeds in the USA. Palmer amaranth resistance to acetolactate synthase (ALS) inhibitors is widespread in the USA, as in Arkansas. The cross‐resistance patterns and mechanism of resistance are not known.
Shilpa Singh +5 more
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