Results 271 to 280 of about 1,479,995 (314)
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Novel target sites in bacteria for overcoming antibiotic resistance

Advanced Drug Delivery Reviews, 2005
Resistance to marketed antibiotics continues to increase. During the last 10 years some 200 bacterial genome sequences have become available, giving rise to expectations that genomics would provide a plethora of novel targets and hence a flood of new therapeutic agents.
Michael T, Black, John, Hodgson
openaire   +2 more sources

Identification and expression of main genes involved in non-target site resistance mechanisms to fenoxaprop-p-ethyl in Beckmannia syzigachne.

Pest Management Science, 2020
BACKGRAOUD Non-target-site resistance (NTSR) to herbicide is a serious threat to global agriculture. Though the metabolic resistance was the dominant mechanism of NTSR, the molecular mechanism is not yet well-characterized.
S. Bai   +6 more
semanticscholar   +1 more source

Cross-resistance to photosystem II inhibitors observed in target site–resistant but not in non–target site resistant common ragweed (Ambrosia artemisiifolia)

Weed Science, 2022
AbstractThe full spectrum of herbicide resistance in a weed can vary according to the mechanistic basis and cannot be implied from the selective pressure. Common ragweed (Ambrosia artemisiifolia L.) is an important weed species of horticultural crops that has developed resistance to linuron based on either target site– or non–target site resistance ...
Martin Laforest   +5 more
openaire   +1 more source

Evidence for the association of target-site resistance in cyp51 with reduced DMI sensitivity in European Cercospora beticola field isolates.

Pest Management Science, 2020
BACKGROUND Cercospora leaf spot caused by Cercospora beticola is the most relevant foliar disease in sugar beet cultivation. In the last decade a decreasing sensitivity of C. beticola towards demethylation inhibitors (DMIs) occurred. Different mechanisms
Maximilian M Muellender   +3 more
semanticscholar   +1 more source

The synergism between metabolic and target-site resistance enhances the intensity of resistance to pyrethroids in Spodoptera exigua.

Insect Biochemistry and Molecular Biology
The widespread application of insecticides imposes intense selective pressure on pest populations, driving the evolution of high-level resistance and leading to frequent control failures in agricultural settings.
Yayun Zuo   +7 more
semanticscholar   +1 more source

Bacterial resistance to antibiotics: Modified target sites

Advanced Drug Delivery Reviews, 2005
Alteration in the target sites of antibiotics is a common mechanism of resistance. Examples of clinical strains showing resistance can be found for every class of antibiotic, regardless of the mechanism of action. Target site changes often result from spontaneous mutation of a bacterial gene on the chromosome and selection in the presence of the ...
openaire   +2 more sources

Altered target sites as a mechanism of herbicide resistance

Crop Protection, 2000
Abstract Over 200 distinct herbicide resistant weed biotypes have evolved worldwide. In most of these, resistance is conferred by an altered target site, i.e. a modified target protein with reduced affinity for the herbicide(s) in question. This has been documented for herbicides that target most major known sites of action, including those that ...
Malcolm D. Devine, Amit Shukla
openaire   +1 more source

Non-target Site Mechanisms of Resistance to Herbicides

Critical Reviews in Plant Sciences, 2017
ABSTRACTEvolution of resistance in weeds to herbicides is threatening world agricultural production. Weed management has become more complicated with the development of non-target site resistance (NTSR) to herbicides in weeds. The NTSR mechanisms can be caused by herbicide metabolism, altered patterns of translocation, and herbicide absorption ...
Hossein Ghanizadeh, Kerry C. Harrington
openaire   +1 more source

Confirmation and Characterization of Non–Target Site Resistance to Fomesafen in Palmer Amaranth (Amaranthus palmeri)

Weed science, 2018
Palmer amaranth (Amaranthus palmeri S. Watson), a dioecious summer annual species, is one of the most troublesome weeds in U.S. cropping systems. The evolution of resistance to protoporphyrinogen oxidase inhibitors in A. palmeri biotypes is a major cause
V. Varanasi   +2 more
semanticscholar   +1 more source

R-factor trimethoprim resistance mechanism: An insusceptible target site

Biochemical and Biophysical Research Communications, 1974
Abstract R-factor R388 increases the resistance of Escherichia coli to trimethoprim by 10,000 fold, and mediates the synthesis of an addional dihydrofolate reductase that is less susceptible to trimethoprim by a similar order of magnitude. The dihydrofolate reductase conferred by the R-factor was of a larger molecular weight than the wild-type ...
S G, Amyes, J T, Smith
openaire   +2 more sources

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