Results 71 to 80 of about 1,394,726 (329)
Insecticide resistance resulting from an absence of target-site gene product [PDF]
Proceedings of the National Academy of Sciences, 1998 Genetic changes in insects that lead to insecticide resistance include point mutations and up-regulation/amplification of detoxification genes. Here, we report a third mechanism, resistance caused by an absence of gene product. Mutations of the Methoprene-tolerant ( Met ) gene of ...
T G, Wilson, M, Ashok
openaire +2 more sources
Julius-Kühn-Archiv, 2012 Neighboring fields in three local areas of southern Germany have been investigated for the infestation level and herbicide resistance structure of black-grass (Alopecurus myosuroides Huds.).
Hess, Martin +5 more
doaj +1 more source
Antimalarial 4(1H)-pyridones bind to the Qisite of cytochromebc1 [PDF]
, 2015 Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of
Antonyuk, SV +10 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
ACCase-inhibiting herbicides: mechanism of action, resistance evolution and stewardship
Scientia Agricola, 2020 Herbicides play an important role in preventing crop yield losses due to both their weed interference ability and their capacity for increasing soil conservation in no-till systems.
Hudson Kagueyama Takano +4 more
doaj +1 more source
Does insecticide resistance contribute to heterogeneities in malaria transmission in The Gambia? [PDF]
, 2016 BACKGROUND: Malaria hotspots, areas with consistently higher than average transmission, may become increasingly common as malaria declines. This phenomenon, currently observed in The Gambia, may be caused by several factors, including some related to the
Crombe, Florence +8 more
core +4 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance [PDF]
Scientific Reports, 2015 AbstractEmergence of genetic resistance against kinase inhibitors poses a great challenge for durable therapeutic response. Here, we report a novel mechanism of JAK2 kinase inhibition by fedratinib (TG101348) that prevents emergence of genetic resistance. Using in vitro drug screening, we identified 211 amino-acid substitutions conferring resistance to
Meenu Kesarwani +10 more
openaire +2 more sources
Is hormesis an underestimated factor in the development of herbicide resistance?
Julius-Kühn-Archiv, 2014 The growing impact of herbicide resistant weeds increasingly affects weed management and the delay of resistance evolution has become a major task of chemical weed control.
Belz, Regina G.
doaj +1 more source
Agronomy, 2020 Corn poppy (Papaver rhoeas L.) and cornflower (Centaurea cyanus L.) are two overwintering weed species found in crop fields in Europe. They are characterised by a similar life cycle, similar competitive efforts, and a spectrum of herbicides recommended ...
Marta Stankiewicz-Kosyl +11 more
doaj +1 more source