Results 61 to 70 of about 5,046,171 (299)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Target strength

, 2016
The target strength distribution of single targets consistent with squid between 900 and 1200 m within three sampling zones (high, alternate, and low Ziphius use)
Southall, Brandon L., Benoit-Bird, Kelly J., Mark A. Moline (278086), Moline, Mark A., Kelly J. Benoit-Bird (290739), Brandon L. Southall (354700)   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Investigations on Target Strength Estimation Methods: A Case Study of Chub Mackerel (Scomber japonicus) in the Northwest Pacific Ocean

Fishes
Target strength (TS) is an acoustic property of individual marine organisms and a critical factor in acoustic resource assessments. However, previous studies have primarily focused on measuring TS at narrowband, typical frequencies, which cannot meet the
Zhenhong Zhu, Jianfeng Tong, Minghua Xue, Chuhan Qiu, Shuo Lyu, Bilin Liu   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ex situ measurement of target strength of tongkol komo (Euthynnus affinis) using broadband echosounder

Depik Jurnal
Target strength (TS) is an important parameter for estimating fish abundance in hydroacoustic surveys by quantifying the acoustic backscatter from individual fish. In this study, the TS of Euthynnus affinis was measured in an acoustic tank using a Simrad
Moh. Rafli Furqan Hidayat, Henry Munandar Manik, Totok Hestirianoto   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Distribusi Target Strength Ikan Demersal Melalui Pengukuran Akustik Secara In-Situ Di Perairan Kahyapu Pulau Enggano Kabupaten Bengkulu Utara

Jurnal Kelautan Tropis
Kahyapu Waters is one of the potential waters for demersal fishing in Enggano Island. Demersal fish resources in Kahyapu Waters if exploited optimally can provide sustainable benefits for local fishermen.
Deddy Bakhtiar, Yordan A Ompusunggu, Ari Anggoro, Supiyati Supiyati   +3 more
doaj   +1 more source