Results 71 to 80 of about 3,861,419 (280)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Engineered bacterial therapy suppresses Enterohemorrhagic Escherichia coli through metabolic competition and virulence silencing

Nature Communications
Enterohemorrhagic Escherichia coli (EHEC) is a severe foodborne pathogen that can lead to hemolytic uremic syndrome. However, antibiotics are contraindicated for EHEC treatment due to toxin release and gut microbiota disruption.
Guozhen Ma, Ruiying Liu, Xueping Li, Jialin Wu, Yuanyuan Niu, Sheng Wang, Ziwei Chen, Xudong Qin, Qian Wang, Junyue Wang, Jiamin Qian, Mingqing Zhang, Yu Pang, Yamin Sun, Guosheng Tang, Tao Wang, Yutao Liu   +16 more
doaj   +1 more source

Research on Lightweight Tracking of Small-Sized UAVs Based on the Improved YOLOv8N-Drone Architecture

Drones
Traditional unmanned aerial vehicle (UAV) detection and tracking methods have long faced the twin challenges of high cost and poor efficiency. In real-world battlefield environments with complex backgrounds, occlusions, and varying speeds, existing ...
Yongjuan Zhao, Qiang Ma, Guannan Lei, Lijin Wang, Chaozhe Guo   +4 more
doaj   +1 more source

Biologically inspired, self organizing communication networks. [PDF]

, 2011
PhDThe problem of energy-efficient, reliable, accurate and self-organized target tracking in Wireless Sensor Networks (WSNs) is considered for sensor nodes with limited physical resources and abrupt manoeuvring mobile targets. A biologically inspired,
Hamouda, Yousef Elabd Mohammad
core   +3 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

On Extended Target Tracking Using PHD Filters [Elektronisk resurs]

, 2012
This paper presents an overview of the extended target tracking research undertaken at the division of Automatic Control at Linköping University. The PHD and CPHD filters for multiple extended target tracking under clutter and unknown association are ...
Gustafsson, Fredrik,, Granström, Karl,, Orguner, Umut,, Lundquist, Christian,   +3 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Dense Target Tracking Algorithm Based on Hierarchical and Gradual Update of Labels with Micro-Motion Characteristics [PDF]

Jisuanji gongcheng
Aiming at the problem of tracking dense target groups, especially multi-targets with micro-motion characteristics, this study proposes a dense target tracking algorithm based on label hierarchical gradual updating with micro-motion characteristics.
CHEN Zhichao, XU Zhenyu, HAO Jinlong, LI Dongying, YU Wenxian
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source