Results 211 to 220 of about 3,752,482 (246)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Targeted anti-CCP testing to identify people at risk of rheumatoid arthritis in primary care: an early economic evaluation. [PDF]

Rheumatol Adv Pract
Smith AF, Shinkins B, Hensor EMA, Wilson M, Anderson AM, Stack R, Emery P, Mankia K, Siddle HJ.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

m6A-Targeted Cancer Therapy: Molecular Targets, Inhibitors, and Nanodelivery Strategies. [PDF]

Int J Nanomedicine
Li C, Guo Y, Jiang W, Xie W, Yao Y.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Adjuvant chemotherapy with or without targeted therapy for patients with resectable synchronous colon cancer and liver or lung-confined metastases: a nationwide Taiwanese database study. [PDF]

ESMO Gastrointest Oncol
Chen PY, Liang YH, Lin BR, Hsu CH, Shao YY.   +4 more
europepmc   +1 more source

Before Reducing Seattle Biopsies, Quantify Their Incremental Dysplasia Yield. [PDF]

United European Gastroenterol J
Wang PF.
europepmc   +1 more source

Nurse-performed POCUS-guided targeted chest physiotherapy in term neonates with severe pneumonia: protocol for a stepped-wedge cluster randomised trial. [PDF]

BMJ Open
Fan Y, Shi Z, Chen W, Ling W, Liu X, Zhang H, Huang S, Qu M, Lin Y, Ouyang X.   +9 more
europepmc   +1 more source

Association between initial treatment strategy and progression to difficult-to-treat rheumatoid arthritis (D2T-RA): evidence from a 20-year-old real-world cohort. [PDF]

RMD Open
Van Mullem C, Natalucci F, Avramovska A, Sokolova T, Triaille C, Durez P.   +5 more
europepmc   +1 more source