Results 101 to 110 of about 1,482,841 (244)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Systematic and Targeted Prostate Biopsy: a Five-Year Experience in a High-Volume Center

Acta Clinica Croatica
Prostate biopsy is the gold standard diagnostic tool for prostate cancer. The number of targeted prostate biopsies based on multiparametric resonance imaging have increased in recent years, and this method is becoming increasingly utilized in patients ...
Toni Zekulić, Tomislav Kuliš, Tvrtko Hudolin, Luka Penezić, Jerko Anđelić, Tomislav Sambolić, Bojan Čikić, Nikola Knežević, Željko Kaštelan   +8 more
doaj   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Comparison of biopsy findings from systematic 12-core biopsy and biparametric MRI targeted biopsy (2 cores per lesion, up to 2 lesions per man).

, 2019
Biopsy findings per patient of systematic 12-core biopsy compared with IMPROD biparametric MRI targeted biopsy for the total cohort of 338 men. Yellow shading indicates men in whom targeted biopsy upgraded the PCa risk category in relation to systematic ...
Sanna Mari Vimpeli (6791459), Pekka Taimen (773545), Jani Saunavaara (6791468), Antti Rannikko (4720587), Outi Oksanen (6791453), Tommi Kauko (773546), Ivan Jambor (5701865), Marjo Seppänen (6791450), Otto Ettala (6791441), Peter J. Boström (470005), Hannu J. Aronen (6791471), Ileana Montoya Perez (2659849), Markku Kallajoki (114542), Aida Kiviniemi (835995), Esa Kähkönen (807207), Tarja Lamminen (6791465), Tuomas Mirtti (155123), Janne Verho (6791438), Juha Knaapila (6791444), Jarno Riikonen (6791456), Harri Merisaari (6791462), Kari T. Syvänen (6791447)   +21 more
core   +1 more source

MRI-targeted, systematic, and combined biopsy for prostate cancer diagnosis

, 2020
Copyright © 2020 Massachusetts Medical Society. BACKGROUND The use of 12-core systematic prostate biopsy is associated with diagnostic inaccuracy that contributes to both overdiagnosis and underdiagnosis of prostate cancer.
Shih, Joanna H., Mehralivand, Sherif, Bloom, Jonathan, Pinsky, Paul, Gomella, Patrick T., Wilbur, Andrew R., Reese, Sarah E., Parnes, Howard, Merino, Maria, Choyke, Peter L., Siddiqui, Minhaj, Turkbey, Baris, Lebastchi, Amir H., Pinto, Peter A., Ahdoot, Michael, Gurram, Sandeep, Wood, Bradford J., Marston Linehan, W.   +17 more
core   +1 more source

Complementary detection of clinically significant prostate cancer by magnetic resonance imaging fusion-targeted and systematic transrectal ultrasound-guided biopsy: influence of prostate-specific antigen and prostate-specific antigen density in a retrospective paired cohort

Prostate International
Background: Multiparametric magnetic resonance imaging (MRI)-targeted biopsy has improved prostate cancer detection, yet the relative diagnostic contributions of MRI-fusion-targeted biopsy and systematic transrectal ultrasound-guided (TRUS) biopsy across
Thanakrit Visuthikosol, Wit Viseshsindh
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Prostate Biopsy Results in the PSA Gray Zone: A Five-Year Retrospective Study

Acta Clinica Croatica
Our aim was to analyze and compare the diagnostic efficacy of systematic and targeted + systematic prostate biopsies in patients with prostate-specific antigen (PSA) levels of 4–10 ng/mL.
Tomislav Kuliš, Toni Kelava, Toni Zekulić, Luka Penezić, Jerko Anđelić, Tomislav Sambolić, Željko Kaštelan   +6 more
doaj   +1 more source