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Target delivery in a microfluidic immunosensor
Biosensors and Bioelectronics, 2007A study is presented that examines the effect of microfluidic mixing elements on direct and sandwich assays performed in microchannels. Patterned grooves were embossed in the top of microchannels made in PDMS using soft lithography. The grooves redirected the fluid flowing in the channel, enhancing delivery of the target from the bulk fluid to the ...
Joel P, Golden +3 more
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Targeted delivery in scleroderma fibrosis
Autoimmunity Reviews, 2021Systemic sclerosis (SSc) is considered one of the most challenging and difficult to treat among rheumatic disorders, due to its severity, multiorgan manifestation and different outcomes. It manifests fibrosis in different organs, mostly in skin and lungs.
Carla, Varrica +4 more
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Syndiotactic peptides for targeted delivery
Acta Biomaterialia, 2019Lack of cell-type specificity and proteolytic susceptibility have long been the major bottlenecks for the development of peptide-based biomaterials for targeted drug delivery. Though a poly-l backbone provides the adaptability to re-conform the peptide structure to bind to a receptor, it also makes the peptide more susceptible to proteolytic cleavage ...
Gaurav Jerath +4 more
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Advances in drug delivery and targeting
Current Opinion in Oncology, 1991This review covers a variety of techniques aimed at improving the specificity of delivery of both biologic and cytotoxic agents to tumor tissue while sparing normal tissue. The major areas reported on include further attempts to increase the ability of monoclonal antibodies, both conjugated and unconjugated, to target tumor tissue. It also examines the
D, Goldstein, C, Lewis
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Targeting and Delivery of Therapeutic Enzymes
Therapeutic Delivery, 2017Biotechnology has revolutionized therapeutics for the treatment of a wide range of diseases. Recent advances in protein engineering and material science have made the targeted delivery of enzyme therapeutics using nanocarriers (NCs) a new model of treatment. Several NCs have been approved for clinical use in drug delivery. Despite their advantages, few
Scott N, Dean +3 more
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Targetable Gene Delivery Vectors
2002Adenoviral vectors, which have targeting ligands for tumor cells on the capsid, no natural tropism, and carry a therapeutic payload should be constructed soon and tested in pre-clinical models. Nevertheless, there are still important considerations for the design and therapeutic use of targetable vectors.
P L, Hallenbeck, S C, Stevenson
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Targeted drug delivery to macrophages
Expert Opinion on Drug Delivery, 2013Targeted drug delivery to the macrophages appears to be an attractive proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.This review discusses the ...
Narendra K, Jain +2 more
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Targeted cytokine delivery to neuroblastoma
Biochemical Society Transactions, 2002The aim of this study was to construct a fusion protein from the cytokine granulocyte/macrophage colony-stimulating factor (GM-CSF) and a single-chain Fv fragment (scFv D29) and to investigate its potential to activate cells of the immune system against neuroblastoma cells expressing neural cell adhesion molecule (NCAM).
P K, Dehal +3 more
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Targeted drug delivery strategies for precision medicines
Nature Reviews Materials, 2021Mandana Manzari +2 more
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