Results 111 to 120 of about 38,995 (207)

Deep Learning Improves Robustness of Voxelwise Kinetic Modeling for Hyperpolarized Carbon‐13 MRI

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate whether deep learning improves the robustness of voxelwise kinetic parameter estimation from hyperpolarized (HP) 13C MRI compared with nonlinear least‐squares (NLLS) fitting. Methods A hybrid neural network (NN) was trained on synthetic pyruvate/lactate time courses generated from an open‐system two‐compartment HP 13C ...
Kofi Deh   +5 more
wiley   +1 more source

A transition zone enriched WIF1+ basal cell subtype is associated with benign prostatic hyperplasia

open access: yesThe Journal of Pathology, EarlyView.
Abstract The cellular composition and disease susceptibilities of the distinct zones of the human prostate remain incompletely understood. Benign prostatic hyperplasia (BPH) is a common condition that causes widespread morbidity and is nearly exclusively localized to the transition zone (TZ).
Rulin Wang   +20 more
wiley   +1 more source

Natural History of PI‐RADS 3 Lesions on Serial Prostate mpMRI

open access: yesThe Prostate, EarlyView.
ABSTRACT Objective PI‐RADS 3 lesions on prostate multiparametric MRI (mpMRI) are indeterminate findings with debated management. We evaluated their radiologic evolution on follow‐up mpMRI and correlated imaging changes with biopsy outcomes. Methods We retrospectively identified 166 men with at least one PI‐RADS 3 lesion on initial mpMRI and at least ...
Tomer Bashi   +13 more
wiley   +1 more source

Prognostic Value of MRI‐Derived Apparent Diffusion Coefficient in Intermediate‐Risk Prostate Cancer Treated With Definitive Radiotherapy

open access: yesThe Prostate, EarlyView.
ABSTRACT Background Intermediate‐risk prostate cancer (IR‐PCa) is a heterogeneous disease with variable clinical outcomes despite established risk classification. We evaluated whether pretreatment tumor apparent diffusion coefficient (ADC) derived from multiparametric MRI was associated with long‐term outcomes and provided additional prognostic ...
Cem Onal   +4 more
wiley   +1 more source

A sample size analysis of a mathematical model of longitudinal tumor volume and progression‐free survival for Bayesian individual dynamic predictions in recurrent high‐grade glioma

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 495-509, March 2025.
Abstract Patients with recurrent high‐grade glioma (rHGG) have a poor prognosis with median progression‐free survival (PFS) of <7 months. Responses to treatment are heterogenous, suggesting a clinical need for prognostic models. Bayesian data analysis can exploit individual patient follow‐up imaging studies to adaptively predict the risk of progression.
Daniel J. Glazar   +5 more
wiley   +1 more source

Transperineal versus transrectal multi-parametric magnetic resonance imaging fusion targeted prostate biopsy. [PDF]

open access: yesSaudi Med J, 2021
Rabah D   +6 more
europepmc   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou   +4 more
wiley   +1 more source

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