Results 71 to 80 of about 5,184,182 (156)
INSIGHTS INTO MOLECULAR GLUE DEGRADERS: A REVIEW [PDF]
Al-Azhar Journal of Pharmaceutical SciencesResearchers in drug discovery are continually investigating new approaches to develop potential anticancer agents that are effective, safe, tolerable, and exhibit reduced resistance.
Mohamed Ayman El-Zahabi +2 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, Volume 600, Issue 17, Page 2437-2450, September 2026.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Recent Advances in CBP/EP300 Degraders
CHIMIATargeted protein degradation (TPD) has emerged as an innovative therapeutic strategy, offering advantage over traditional approaches rooted in small-molecule inhibitors.
Leonardo Palaferri +2 more
doaj +1 more source
SE(3)-equivariant ternary complex prediction towards target protein degradation
Nature CommunicationsTargeted protein degradation (TPD) has rapidly emerged as a powerful modality for drugging previously “undruggable” proteins. TPD employs small molecules like PROTACs and molecular glue degraders (MGD) to induce target protein degradation via the ...
Fanglei Xue +7 more
doaj +1 more source
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology [PDF]
Targeted protein degradation (TPD) has emerged as a transformative therapeutic strategy for eliminating disease‐associated proteins, with relevance across disorders ranging from cancer to neurodegeneration. Since its inception nearly two decades ago, TPD
core +10 more sources
Targeted protein degradation technologies: Emerging mechanisms and nano-based innovations
Nano ResearchTargeted protein degradation (TPD) technologies have emerged as a powerful strategy for eliminating disease-causing proteins by hijacking endogenous degradation systems. Over the past decade, multiple TPD modalities—such as proteolysis-targeting chimeras
Mingge Hou +4 more
doaj +1 more source
Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation
Advanced ScienceProteolysis targeting chimeras (PROTACs) have emerged as an intriguing therapeutic strategy for targeted protein degradation (TPD), functioning as heterobifunctional compounds that induce the redirection of E3 ligases to ubiquitinate neo‐substrates for ...
Guanjun Dong +13 more
doaj +1 more source
Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation
MedComm – Biomaterials and ApplicationsLysosome‐targeting chimeras (LYTACs) represent a novel class of targeted protein degradation (TPD) technologies that utilize lysosome‐targeting receptors (LTRs) to degrade extracellular and membrane‐bound proteins.
Lijian Shen +4 more
doaj +1 more source
Site-resolved assessment of targeted protein degradation [PDF]
Induced proximity using small molecules, exemplified by Targeted Protein Degradation (TPD), represents a highly promising therapeutic strategy with significant untapped potential.
Virdee, Satpal; id_orcid +3 more
core +1 more source
Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
Frontiers in Molecular NeuroscienceTargeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs (proteolysis-targeting chimeras) in clinical trials and molecular glues such as immunomodulatory imide drugs (IMiDs) already well established in the treatment of ...
Sandra Kuemper +4 more
doaj +1 more source