Results 51 to 60 of about 8,056 (296)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Regime Type, Issue Type and Economic Sanctions: The Role of Domestic Players

open access: yesEconomies, 2019
This analysis highlights the significant role that domestic actors play in determining the outcomes of economic sanctions. It models the behavior of the main opposition party during an economic sanction episode, and introduces two commonly used variables
Mehmet Onder
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Sanctions compliance as a basis for non-performance of contractual obligations

open access: yesJournal of Economic Criminology
Targeted financial sanctions are routinely used to combat financial crime. As they are endorsed by the United Nations and the Financial Action Task Force, the vast majority of jurisdictions have established regulatory frameworks that make provision for ...
Cayle Lupton
doaj   +1 more source

The Efficacy of Targeted Sanctions in Enforcing Compliance with International Law

open access: yesAJIL Unbound, 2019
In the international legal order, sanctions are valued for their coercive and stigmatizing functions. Through the imposition of financial or other costs, these measures seek to induce compliance with international law by those who are targeted. They also
Alexandra Hofer
doaj   +1 more source

Sanctions in U.S. - Russia Relations

open access: yesVestnik RUDN. International Relations, 2020
Given America’s leading position in the global economy, the U.S. government has frequently leveraged that power to punish “rogue states”, discourage nuclear proliferation, promote democratization, and create pressure for regime change.
Charles E. Ziegler
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The Status of Sanctions in US Foreign Policy: A Study on the Magnitsky Act

open access: yesقضايا سياسية
This research examines the role of sanctions in American foreign policy through a case study of the Magnitsky Act and its implications for human rights and international relations.
Zainab Hassan Khalaf
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Technological sanctions, research capacity, and unintended consequences

open access: yesInternational Review of Economics & Finance
This study examines the impact of technological sanctions on global competition, highlighting that their outcomes depend significantly on the research capacities of the targeted countries.
Chu-Ping Lo
doaj   +1 more source

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