Cyclotron-Based Production of 67Cu for Radionuclide Theranostics via the 70Zn(p,α)67Cu Reaction [PDF]
Pharmaceuticals, 2023 Theranostic matched pairs of radionuclides have aroused interest during the last couple of years, and in that sense, copper is one element that has a lot to offer, and although 61Cu and 64Cu are slowly being established as diagnostic radionuclides for ...
Santiago Andrés Brühlmann +6 more
doaj +2 more sources
Is 70Zn(d,x)67Cu the Best Way to Produce 67Cu for Medical Applications? [PDF]
Frontiers in Medicine, 2021 The pair of copper radionuclides 64Cu/67Cu (T1/2 = 12. 7 h/61.8 h) allows, respectively, PET imaging and targeted beta therapy. An analysis of the different production routes of 67Cu with charged particles was performed and the reaction 70Zn(d,x) route ...
Etienne Nigron +5 more
doaj +2 more sources
Developments toward the Implementation of 44Sc Production at a Medical Cyclotron [PDF]
Molecules, 2020 44Sc has favorable properties for cancer diagnosis using Positron Emission Tomography (PET) making it a promising candidate for application in nuclear medicine.
Nicholas P. van der Meulen +9 more
doaj +2 more sources
Toward Personalized Immunotherapeutic Drug Monitoring with Multiplexed Extended-Gate Field-Effect-Transistor Biosensors. [PDF]
Small SciIn this study, a proof of concept is presented using an extended‐gate field‐effect‐transistor biosensing platform for monitoring immunotherapeutic drugs in vivo. Using varying sizes of immunotherapeutic drugs, the biosensor surpasses the sensitivity of standard methods, reducing the need for radioactive labeling in real‐time sensing.
Nguyen-Le TA +8 more
europepmc +2 more sources
A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with 68Ga, 44Sc, 177Lu and 161Tb [PDF]
Molecules, 2020 The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases.
Zeynep Talip +3 more
doaj +2 more sources
Instruments, 2018 The present work describes an experimental system enabling temperature measurement in cyclotron targets’ cooling water during bombardment. The developed system provides sensible and immediate response to variations of irradiation conditions during ...
Sérgio J C Do Carmo +2 more
exaly +3 more sources
In-target production of [11C]CH4 from a nitrogen/hydrogen gas target as a function of beam current, irradiation time, and target temperature [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Production of [11C]CH4 from gas targets is notorious for weak performance with respect to yield, especially when using high beam currents. Post-target conversion of [11C]CO2 to [11C]CH4 is a widely used roundabout method in 11C-radiochemistry,
Semi Helin +5 more
doaj +2 more sources
High energy implementation of coil-target scheme for guided re-acceleration of laser-driven protons [PDF]
Scientific Reports, 2021 Developing compact ion accelerators using intense lasers is a very active area of research, motivated by a strong applicative potential in science, industry and healthcare.
Hamad Ahmed +17 more
doaj +2 more sources
A new approach to targetry and cyclotron production of 45Ti by proton irradiation of 45Sc [PDF]
Nuclear Technology and Radiation Protection, 2014 Titanium-45 with a half-life of 3.09 hours decays by emission of positrons (85%) and the electron capture process (15%). These properties make this radionuclide useful in the diagnosis of tumors by positron emission tomography.
Yousef Fazaeli
exaly +2 more sources
Solving the limited availability of Astatine-211 from a European perspective: from production to the end user [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Astatine-211, 211At, has long been a candidate for Targeted Alpha Therapy, TAT. However, over time, hurdles in the development of chemistry, the establishment of radiopharmacies, and the demonstration of its potential in clinical trials have ...
Sture Lindegren +5 more
doaj +2 more sources