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Current Advances of Drug Target Research in Medicinal Chemistry
Current Topics in Medicinal Chemistry, 2019 Guo-Ping Zhou
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In Vivo Targeting through Click Chemistry [PDF]
ChemMedChem, 2015 AbstractTargeting small molecules to diseased tissues as therapy or diagnosis is a significant challenge in drug delivery. Drug‐eluting devices implanted during invasive surgery allow the controlled presentation of drugs at the disease site, but cannot be modified once the surgery is complete.
Brudno, Yevgeny +5 more
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Targeting biomolecules with reversible covalent chemistry [PDF]
Current Opinion in Chemical Biology, 2016 Interaction of biomolecules typically proceeds in a highly selective and reversible manner, for which covalent bond formation has been largely avoided due to the potential difficulty of dissociation. However, employing reversible covalent warheads in drug design has given rise to covalent enzyme inhibitors that serve as powerful therapeutics, as well ...
Anupam, Bandyopadhyay, Jianmin, Gao
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Supramolecular Chemistry Targeting Proteins
Journal of the American Chemical Society, 2017 The specific recognition of protein surface elements is a fundamental challenge in the life sciences. New developments in this field will form the basis of advanced therapeutic approaches and lead to applications such as sensors, affinity tags, immobilization techniques, and protein-based materials.
Sam van Dun +3 more
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Improvements in iridium target chemistry
Journal of Radioanalytical and Nuclear Chemistry, 2023 AbstractWe developed and optimized the dissolution and separation chemistry of iridium (Ir) from irradiated Ir pellets and prepared Ir counting samples for analysis by a silicon drift detector. Previous Ir chemistry techniques used on the irradiated Ir pellets are tedious, lengthy, and require extra safety precautions and planning due to the use of ...
Athena M. Marenco +3 more
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NO•chemistry: a diversity of targets in the cell [PDF]
Redox Report, 2006 NO(*) alone is a poorly reactive species; however, it is able to undergo secondary reactions to form highly oxidizing and nitrating species, NO(2)(*), N(2)O(3), and ONOO(-). These secondary reactive nitrogen species (RNS) are capable of modifying a diversity of biomolecular structures in the cell.
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Engineering chemistry to meet COP26 targets [PDF]
Nature Reviews Chemistry, 2021 Ryan, A.J., Rothman, R.H.
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Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets [PDF]
, 2020 Brandon L. Greene +6 more
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Bioorthogonal chemistries for nanomaterial conjugation and targeting
Nanotechnology Reviews, 2013 AbstractBioorthogonal chemistries are covalent reaction pairs that proceed in the presence of biological components with complete specificity. A suite of reactions has been described to date that provides scientists and engineers with diverse operational characteristics for different applications.
Maha K. Rahim +3 more
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Targeted Fluorogenic Cyanine Carbamates Enable In Vivo Analysis of Antibody-Drug Conjugate Linker Chemistry [PDF]
, 2021 Syed Muhammad Usama +7 more
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