Results 191 to 200 of about 2,620,157 (317)

Important Marine Mammal Areas celebrated—yet some are now in danger

Oryx
Erich Hoyt, Gill Braulik, Caterina Lanfredi, Gianna Minton, Simone Panigada, Elena Politi, Margherita Zanardelli, Giuseppe Notarbartolo di Sciara   +7 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Real-time cognitive-affective dynamics of failure feedback in a technology-based learning task. [PDF]

Commun Psychol
Ackermann H, Lange AL, Dumont H, Hafner VV, Lazarides R.   +4 more
europepmc   +1 more source

Numeral selection task as a variable task-switching task

Proceedings of the Japanese Society for Cognitive Psychology, 2009
Harada, Etsuko, T., Asano, Akihiro, Suto, Satoru, Hasher,, Lynn   +3 more
openaire   +1 more source

Implicit Sequence Learning in Children With Reading Difficulties: Dyslexia Versus Low Intellectual Functioning. [PDF]

Dyslexia
Vaquero JMM, Simpson IC, Defior S, Jiménez-Fernández G.   +3 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The TASK-1 and TASK-3 activator JG-C3-98 attenuates cold and mechanical responses in primary somatosensory neurons. [PDF]

Front Pharmacol
De-la-Torre P, Valencia M, Gálvez J, Flores Del Pino V, Gómez Del Campo A, Romero S, Mendoza E, Rinné S, Kiper A, Prent L, Vergara-Jaque A, Mazola Y, Olivera-Fuentes C, Zúñiga R, Márquez Montesinos JCE, Rojas B, Peña L, Quiroga J, Pertusa M, Decher N, Zúñiga L, González W, Madrid R.   +22 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Is multitasking efficient? Different metrics, different conclusions. [PDF]

Psychol Res
Jung AC, Janczyk M, Manzey D, Fischer R.
europepmc   +1 more source