Results 81 to 90 of about 7,344,765 (259)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A model of learning task-specific knowledge for a new task [PDF]
, 1999 In this paper I will present a detailed ACT-R model of how the task-specific knowledge for a new, complex task is learned. The model is capable of acquiring its knowledge through experience, using a declarative representation that is gradually compiled ...
Taatgen, Niels A.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Enseignement de l’oral à l’université en Algérie et Cadre Européen Commun de Référence
Multilinguales, 2016 The present article is the synthesis of a research carried out in the French section of the Department of Letters and Foreign Languages, at Tiaret University, Algeria.
Hamida Doulate Serouri
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Methodological Approach to Determining Labor Consumption to Perform Scientific-Research Work
Учёт. Анализ. Аудит, 2019 Currently organizations of the military-industrial complex do not possess adequate methodological means to draw up an educated position in order to coordinate the labor-output ratio with the experts of the military representative office of the Ministry ...
ALEXANDER G. Podolsky, ALEXEJ V Babkin
doaj +1 more source
HELIN Professional Development Task Force Final Report [PDF]
, 2011 Final Report of the Professional Development Task Force of the HELIN Consortium ...
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Creative going near organization of work on physical education at modern general school [PDF]
Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012 The parameters of stimulation independently of creative activity of future teachers of physical education are lighted up during development of pedagogical creation.
Sushchenko A.V.
doaj