Results 111 to 120 of about 3,244,349 (297)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Revista Latino-Americana de Enfermagem, 2008 Hypertension is related to the incidence of cardiovascular diseases. Family support is essential for the patient to control the disease. This study aimed to analyze whether the family positively contributes to the patient's control of the disease.
Rosana dos Santos Costa +1 more
doaj +1 more source
Adaptive planning for distributed systems using goal accomplishment tracking [PDF]
, 2015 Goal accomplishment tracking is the process of monitoring the progress of a task or series of tasks towards completing a goal. Goal accomplishment tracking is used to monitor goal progress in a variety of domains, including workflow processing ...
Lee, K, Mann, G, Small, N
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Revista Colombiana de Cirugía, 2005 Hipótesis: El sistema robótico da Vinci™ permite superar las limitaciones que impone al cirujano la cirugía mínimamente invasora en términos de destreza, control del campo operatorio y ergonomía.
Juan David Hernández +5 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Using entropy-based local weighting to improve similarity assessment [PDF]
, 2002 This paper enhances and analyses the power of local weighted similarity measures. The paper proposes a new entropy-based local weighting algorithm to be used in similarity assessment to improve the performance of the CBR retrieval task.
Comas, Joaquim +5 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Journal of Rehabilitation MedicineObjective: To clarify the percentage of stroke patients who are independent in performing tasks involved in public transportation use and problems faced while doing so. Design: Single-institution retrospective study.
Shin Kitamura +5 more
doaj +1 more source