Results 91 to 100 of about 1,766,433 (345)

Tackling Exascale Software Challenges in Molecular Dynamics Simulations with GROMACS

, 2015
GROMACS is a widely used package for biomolecular simulation, and over the last two decades it has evolved from small-scale efficiency to advanced heterogeneous acceleration and multi-level parallelism targeting some of the largest supercomputers in the ...
A Arnold, A Faradjian, B Hess, C Schütte, G Wilson, JA Anderson, JC Phillips, KJ Bowers, KJ Bowers, L Verlet, M Eleftheriou, M Shirts, MJ Abraham, P Eastman, R Yokota, S Pronk, S Páll, U Essmann, W Humphrey, WM Brown, Y Andoh, Y Sugita   +21 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

SISTEM MANAJEMEN PROYEK BERBASIS ONLINE MENGGUNAKAN ORACLE [PDF]

, 2011
In project management activities required good coordination and cooperation between divisions of a compact team for executing the project. During this time, the conventional makes project planning, review and evaluate the tasks of the project, its need ...
ASMARA, RENGGA, BASOFI, ARIF, Yuniamarta, Khrisna   +2 more
core  

Selection method of the project management methodology and its application [PDF]

, 2013
The task of selecting the methodology for managing a specific project is analyzed. The method, consisting of 2 stages, is suggested. At the first stage a project manager has to fill out a questionnaire.
Iranik, N., Kharazii, Anna, Kononenko, Igor   +2 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Project Management Roles and Task for Interior Designer During Design Phase

, 2021
Nur Maizura Ahmad Noorhani, Arniatul Aiza Mustapha, Hamimah Adnan   +2 more
openalex   +2 more sources

Projectification of the Firm : the Renault Case [PDF]

Many industrial firms are implementing fundamental changes in their organizations to increase the efficiency of their product development processes.
Christophe Midler
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Optimization of Resource Allocation and Task Allocation with Project Management Information Systems in Information Technology Companies [PDF]

, 2023
Ilham Nur Pratama, M. Dachyar, Novandra Rhezza Pratama   +2 more
openalex   +1 more source

Management of interdisciplinary project approaches in Engineering Education: a case study [PDF]

, 2009
This paper describes project management processes of coordination teams, in the implementation of interdisciplinary project approaches in Engineering Education.
Alves, Anabela Carvalho, Carvalho, Dinis, Lima, Rui M., Sousa, Rui M.   +3 more
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